cliot (version 1.0.0)

duke_endocarditis_criteria: Modified Duke Criteria for Infective Endocarditis

Description

Calculates the classification (Definite, Possible, or Rejected) for Infective Endocarditis based on the Modified Duke Criteria. This set of diagnostic criteria integrates pathologic, clinical, laboratory, and echocardiographic findings.

Usage

duke_endocarditis_criteria(pathologic_lesions, major_blood_cultures,
                           major_echo, predisposition_heart_condition,
                           fever_gt_38, vascular_phenomena,
                           immunologic_phenomena, minor_blood_culture_findings)

Value

A list containing:

Classification

"Definite Infective Endocarditis", "Possible Infective Endocarditis", or "Rejected".

Criteria_Met

Summary of the counts of Major and Minor criteria identified.

Arguments

pathologic_lesions

Numeric (0 or 1). Pathologic lesions (vegetation or intracardiac abscess) demonstrating active endocarditis on histology OR microorganisms demonstrated by culture/histology of vegetation/emboli. (1 = Yes).

major_blood_cultures

Numeric (0 or 1). Positive blood cultures meeting specific criteria (typical microorganisms consistent with IE from 2 separate cultures, persistent positive cultures, or single positive for Coxiella burnetii). (1 = Yes).

major_echo

Numeric (0 or 1). Evidence of endocardial involvement (vegetation, abscess, new partial dehiscence of prosthetic valve, or new valvular regurgitation). (1 = Yes).

predisposition_heart_condition

Numeric (0 or 1). Predisposing heart condition or intravenous drug use. (1 = Yes).

fever_gt_38

Numeric (0 or 1). Fever >= 38.0 C (100.4 F). (1 = Yes).

vascular_phenomena

Numeric (0 or 1). Major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, or Janeway lesions. (1 = Yes).

immunologic_phenomena

Numeric (0 or 1). Glomerulonephritis, Osler's nodes, Roth spots, or Rheumatoid factor. (1 = Yes).

minor_blood_culture_findings

Numeric (0 or 1). Microbiologic evidence (positive blood culture but does not meet major criteria, or serologic evidence of active infection with organism consistent with IE). (1 = Yes).

References

Li JS, Sexton DJ, Mick N, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30(4):633-638. doi:10.1086/313753

Examples

# Example 1: Definite IE (1 Major + 3 Minor)
# Major Echo, Fever, Vascular, Immunologic
duke_endocarditis_criteria(0, 0, 1, 0, 1, 1, 1, 0)

# Example 2: Possible IE (3 Minor)
# Fever, Predisposition, Minor Culture
duke_endocarditis_criteria(0, 0, 0, 1, 1, 0, 0, 1)