cliot (version 1.0.0)

dutch_lipid_clinic_score: Dutch Lipid Clinic Network Criteria for Familial Hypercholesterolemia (FH)

Description

Calculates the Dutch Lipid Clinic Network (DLCN) score to assess the likelihood of Familial Hypercholesterolemia (FH) in an individual. The score aggregates points from family history, clinical history, physical examination, LDL cholesterol levels, and DNA analysis.

Usage

dutch_lipid_clinic_score(ldl_cholesterol, family_history_score,
                         personal_premature_cad,
                         personal_premature_cerebral_peripheral,
                         exam_tendon_xanthoma, exam_arcus_cornealis_lt45,
                         genetic_mutation, ldl_units = "mg/dL")

Value

A list containing:

DLCN_Score

The calculated total score.

Diagnosis

Classification (Unlikely <3, Possible 3-5, Probable 6-8, Definite >8).

Arguments

ldl_cholesterol

Numeric. Pre-treatment LDL cholesterol level.

family_history_score

Numeric (0, 1, or 2). Points assigned for family history (choose the highest applicable): 0: None. 1: 1st-degree relative with premature coronary/vascular disease OR 1st-degree relative with LDL >95th percentile. 2: 1st-degree relative with tendon xanthomas/corneal arcus OR Child <18 with LDL >95th percentile.

personal_premature_cad

Numeric (0 or 1). Patient has premature coronary artery disease (Men <55, Women <60). (1 = Yes, +2 pts).

personal_premature_cerebral_peripheral

Numeric (0 or 1). Patient has premature cerebral or peripheral vascular disease (Men <55, Women <60). (1 = Yes, +1 pt).

exam_tendon_xanthoma

Numeric (0 or 1). Tendon xanthomas present on examination. (1 = Yes, +6 pts).

exam_arcus_cornealis_lt45

Numeric (0 or 1). Arcus cornealis present prior to age 45. (1 = Yes, +4 pts). Note: If both xanthoma and arcus are present, usually only the higher score (6) is applied for the exam category.

genetic_mutation

Numeric (0 or 1). Functional mutation in LDLR, APOB, or PCSK9 gene present. (1 = Yes, +8 pts).

ldl_units

String. Units for LDL input. "mg/dL" (default) or "mmol/L".

References

World Health Organization. Familial hypercholesterolaemia (FH): Report of a second WHO consultation. Geneva. 1999.

Examples

# Example 1: Definite FH
# LDL 350 mg/dL (+8), Tendon Xanthomas (+6)
# Score = 14
dutch_lipid_clinic_score(350, 0, 0, 0, 1, 0, 0)

# Example 2: Possible FH
# LDL 160 mg/dL (+1), Premature CAD (+2)
# Score = 3
dutch_lipid_clinic_score(160, 0, 1, 0, 0, 0, 0)