cliot (version 1.0.0)

duval_cibmtr_aml_survival: Duval/CIBMTR Score for AML Survival

Description

Calculates the Duval/CIBMTR score to predict 3-year overall survival in patients with active Acute Myelogenous Leukemia (AML) undergoing hematopoietic cell transplantation (HCT). The score stratifies patients based on disease status, cytogenetics, donor match, circulating blasts, and performance status.

Usage

duval_cibmtr_aml_survival(disease_group, cytogenetics, hla_match,
                          circulating_blasts, karnofsky_score)

Value

A list containing:

Duval_CIBMTR_Score

The calculated score (Range 0-6).

Estimated_3_Year_Survival

The predicted 3-year overall survival probability.

Arguments

disease_group

Numeric (0 or 1). Disease status group. 0: Primary induction failure OR Duration of first complete remission > 6 months. 1: Duration of first complete remission < 6 months (or relapse within 6 months).

cytogenetics

Numeric (0 or 1). Cytogenetic risk group. 0: Good or Intermediate. 1: Poor.

hla_match

Numeric (0 or 1). Donor HLA match type. 0: HLA-identical sibling or well-matched/partially-matched unrelated donor. 1: Mismatched unrelated donor or related other than HLA-identical sibling. (+2 points).

circulating_blasts

Numeric (0 or 1). Presence of circulating blasts at the time of transplant. (1 = Present, +1 point).

karnofsky_score

Numeric (0 or 1). Karnofsky Performance Status (KPS) or Lansky scale. 0: 90-100. 1: < 90. (+1 point).

References

Duval M, Klein JP, He W, et al. Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure. J Clin Oncol. 2010;28(23):3730-3738. doi:10.1200/JCO.2010.28.8852

Examples

# Example 1: Good Prognosis
# CR1 > 6mo (0), Good Cyto (0), Matched Sib (0), No Blasts (0), KPS 90 (0)
# Score = 0
duval_cibmtr_aml_survival(0, 0, 0, 0, 0)

# Example 2: Poor Prognosis
# CR1 < 6mo (1), Poor Cyto (1), Mismatched Donor (1 -> +2pts), Blasts Present (1), KPS 80 (1)
# Score = 1 + 1 + 2 + 1 + 1 = 6
duval_cibmtr_aml_survival(1, 1, 1, 1, 1)