cliot (version 1.0.0)

estimate_toxic_alcohol_level: Estimated Serum Concentration for Toxic Alcohols

Description

Calculates the theoretical peak serum concentration of Ethanol, Methanol, Ethylene Glycol, or Isopropanol following an acute ingestion. The estimation uses the Widmark formula variant: $$Cp = \frac{Volume \times Concentration \times SpecificGravity}{Weight \times Vd}$$ where Cp is the peak concentration.

Usage

estimate_toxic_alcohol_level(substance, volume_ingested, volume_units,
                             concentration_percent, weight_kg, sex = "male")

Value

A list containing:

Estimated_Peak_Concentration_mg_dL

The calculated peak serum level in mg/dL.

Interpretation

Clinical context regarding toxic thresholds (e.g., treatment indication for methanol/ethylene glycol at >20 mg/dL).

Arguments

substance

String. The ingested substance. Options: "ethanol", "methanol", "ethylene_glycol", "isopropanol".

volume_ingested

Numeric. The volume of liquid ingested.

volume_units

String. Units of volume. Options: "mL", "oz", "L".

concentration_percent

Numeric. The concentration of the substance in percent (e.g., 40 for 80-proof vodka, 95 for antifreeze).

weight_kg

Numeric. Patient weight in kilograms.

sex

String. Patient sex ("Male" or "Female"). Primarily affects the Volume of Distribution (Vd) used for Ethanol calculations.

References

Widmark EMP. Principles and Applications of Medicolegal Alcohol Determination. Biomedical Publications. 1981. (Original derivation). Goldfrank's Toxicologic Emergencies. (Standard toxicology reference for Vd and SG values).

Examples

# Example 1: Methanol Ingestion
# 100 mL of 100% Methanol, 70kg person
estimate_toxic_alcohol_level("methanol", 100, "mL", 100, 70)

# Example 2: Ethanol Intoxication
# 500 mL of 40% Vodka, 80kg Male
# SG ~0.79, Vd ~0.7
estimate_toxic_alcohol_level("ethanol", 500, "mL", 40, 80, "male")