cliot (version 1.0.0)

eutos_cml_score: EUTOS Score for Chronic Myelogenous Leukemia (CML)

Description

Calculates the EUTOS (European Treatment and Outcome Study) score to predict the likelihood of achieving Complete Cytogenetic Response (CCyR) at 18 months in newly diagnosed CML patients treated with Tyrosine Kinase Inhibitors (TKIs). The score uses the percentage of basophils in peripheral blood and spleen size measured below the costal margin.

Usage

eutos_cml_score(basophils_percent, spleen_size_cm)

Value

A list containing:

EUTOS_Score

The calculated prognostic score.

Risk_Category

"Low Risk" (Score <= 87) or "High Risk" (Score > 87).

Arguments

basophils_percent

Numeric. Percentage of basophils in peripheral blood.

spleen_size_cm

Numeric. Spleen size measured as the maximum distance palpable below the costal margin in centimeters.

References

Hasford J, Baccarani M, Hoffmann V, et al. Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood. 2011;118(3):686-692. doi:10.1182/blood-2010-12-325548

Examples

# Example 1: Low Risk
# Basophils 2%, Spleen 0 cm
# Score = (7*2) + (4*0) = 14
eutos_cml_score(2, 0)

# Example 2: High Risk
# Basophils 8%, Spleen 10 cm
# Score = (7*8) + (4*10) = 56 + 40 = 96
eutos_cml_score(8, 10)