cliot (version 1.0.0)

fomepizole_dosing: Fomepizole Dosing for Toxic Alcohol Ingestion

Description

Calculates the recommended weight-based dosing regimen for Fomepizole (Antizol), an antidote used in confirmed or suspected ethylene glycol or methanol poisoning. The standard protocol involves a loading dose followed by maintenance doses, with specific frequency adjustments required during hemodialysis due to the drug's dialyzability.

Usage

fomepizole_dosing(weight_kg, on_hemodialysis = 0)

Value

A list containing:

Weight_Used_kg

The weight used for calculations.

Calculated_Dosing_Regimen

A list detailing the Loading Dose, Maintenance Doses (Initial and Prolonged), and specific adjustments for dialysis if applicable.

Arguments

weight_kg

Numeric. Patient's actual body weight in kilograms.

on_hemodialysis

Numeric (0 or 1). Is the patient currently undergoing or about to undergo hemodialysis? (1 = Yes, 0 = No). This alters the recommended dosing frequency.

References

Antizol (fomepizole) [package insert]. Jazz Pharmaceuticals, Inc. Palo Alto, CA; 2021. Brent J, McMartin K, Phillips S, et al. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. N Engl J Med. 1999;340(11):832-838. doi:10.1056/NEJM199903183401102

Examples

# Example 1: Standard Patient
# 70 kg, not on dialysis
fomepizole_dosing(70, 0)

# Example 2: Patient on Dialysis
# 80 kg, active hemodialysis
fomepizole_dosing(80, 1)