cliot (version 1.0.0)

gelf_criteria_follicular_lymphoma: GELF Criteria for Follicular Lymphoma

Description

Evaluates the Groupe d'Etude des Lymphomes Folliculaires (GELF) criteria to determine tumor burden in patients with follicular lymphoma. The presence of at least one criterion indicates high tumor burden, suggesting the need to initiate therapy rather than a "watch and wait" approach.

Usage

gelf_criteria_follicular_lymphoma(nodal_mass_gt_7cm, multiple_nodal_sites_gt_3cm,
                                  systemic_symptoms, spleen_enlargement,
                                  organ_compression, pleural_ascitic_effusion,
                                  ldh_or_beta2_elevated)

Value

A list containing:

GELF_Result

"High Tumor Burden" if >= 1 criterion is met, otherwise "Low Tumor Burden".

Criteria_Count

Total number of positive criteria.

Recommendation

Clinical guidance regarding treatment initiation.

Arguments

nodal_mass_gt_7cm

Numeric (0 or 1). Presence of a nodal mass > 7 cm. (1 = Yes).

multiple_nodal_sites_gt_3cm

Numeric (0 or 1). Involvement of >= 3 nodal sites, each > 3 cm. (1 = Yes).

systemic_symptoms

Numeric (0 or 1). Presence of systemic symptoms (B symptoms: fever, night sweats, weight loss >10%). (1 = Yes).

spleen_enlargement

Numeric (0 or 1). Symptomatic splenic enlargement (splenomegaly). (1 = Yes).

organ_compression

Numeric (0 or 1). Compression of a vital organ (e.g., ureteral obstruction, SVC syndrome). (1 = Yes).

pleural_ascitic_effusion

Numeric (0 or 1). Presence of pleural effusion or ascites. (1 = Yes).

ldh_or_beta2_elevated

Numeric (0 or 1). Elevated serum LDH or Beta-2 Microglobulin levels. (1 = Yes).

References

Brice P, Bastion Y, Lepage E, et al. Comparison in low-tumor-burden follicular lymphomas between an initial no-treatment policy, prednimustine, or interferon alfa: a randomized study from the Groupe d'Etude des Lymphomes Folliculaires. Groupe d'Etude des Lymphomes Folliculaires. J Clin Oncol. 1997;15(3):1110-1117. doi:10.1200/JCO.1997.15.3.1110

Examples

# Example 1: High Burden (Need Treatment)
# Large mass > 7cm, No other symptoms
gelf_criteria_follicular_lymphoma(1, 0, 0, 0, 0, 0, 0)

# Example 2: Low Burden (Watch and Wait)
# No criteria met
gelf_criteria_follicular_lymphoma(0, 0, 0, 0, 0, 0, 0)