cliot (version 1.0.0)

gigpa_score: GI-GPA (Graded Prognostic Assessment for Gastrointestinal Cancers)

Description

Calculates the GI-GPA score, a prognostic index for patients with brain metastases from gastrointestinal cancers. The score uses four factors: Karnofsky Performance Status (KPS), age, presence of extracranial metastases, and number of brain metastases to predict median survival.

Usage

gigpa_score(kps, age, extracranial_metastases, num_brain_metastases)

Value

A list containing:

GI_GPA_Score

The calculated prognostic score (Range 0.0 - 4.0).

Median_Survival

Estimated median survival time in months.

Arguments

kps

Numeric. Karnofsky Performance Status score (0-100). >=90: 2.0 pts. 80: 1.5 pts. 70: 1.0 pt. <70: 0 pts.

age

Numeric. Patient age in years. <70: 0.5 pts. >=70: 0 pts.

extracranial_metastases

Numeric (0 or 1). Presence of extracranial metastases. (1 = Present: 0 pts, 0 = Absent: 1.0 pt).

num_brain_metastases

Numeric. Number of brain metastases. 1: 0.5 pts. >1: 0 pts.

References

Sperduto PW, Kased N, Roberge D, et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol. 2012;30(4):419-425. doi:10.1200/JCO.2011.38.0527

Examples

# Example 1: Good Prognosis
# KPS 90 (+2.0), Age 60 (+0.5), No extra mets (+1.0), 1 brain met (+0.5)
# Score = 4.0
gigpa_score(90, 60, 0, 1)

# Example 2: Poor Prognosis
# KPS 60 (0), Age 75 (0), Extra mets (+0), >1 brain met (0)
# Score = 0.0
gigpa_score(60, 75, 1, 3)