cliot (version 1.0.0)

glasgow_alcoholic_hepatitis_score: Glasgow Alcoholic Hepatitis Score (GAHS)

Description

Calculates the Glasgow Alcoholic Hepatitis Score (GAHS) to predict the prognosis of patients with alcoholic hepatitis. The score ranges from 5 to 12, based on Age, White Blood Cell count, Urea, Prothrombin Time (INR), and Bilirubin. A score of 9 or higher indicates a poor prognosis and may guide the use of corticosteroids (specifically for patients with a discriminant function >= 32).

Usage

glasgow_alcoholic_hepatitis_score(age, wbc_count, urea, pt_inr, bilirubin,
                                  bilirubin_units = "mg/dL", urea_units = "mg/dL")

Value

A list containing:

GAHS_Score

The calculated score (Range 5-12).

Survival_28_Day

Estimated 28-day survival percentage.

Survival_84_Day

Estimated 84-day survival percentage.

Arguments

age

Numeric. Patient age in years. (<50: 1 pt, >=50: 2 pts).

wbc_count

Numeric. White Blood Cell count in 10^9/L. (<15: 1 pt, >=15: 2 pts).

urea

Numeric. Blood Urea Nitrogen (BUN) or Urea. (<5 mmol/L: 1 pt, >=5 mmol/L: 2 pts).

pt_inr

Numeric. INR ratio. (<1.5: 1 pt, 1.5-2.0: 2 pts, >=2.0: 3 pts).

bilirubin

Numeric. Total Bilirubin level. (<125 umol/L: 1 pt, 125-250: 2 pts, >=250: 3 pts).

bilirubin_units

String. Units for bilirubin. "mg/dL" (default) or "umol/L".

urea_units

String. Units for urea input. "mg/dL" (default, assumed BUN) or "mmol/L".

References

Forrest EH, Evans CD, Stewart S, et al. Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score. Gut. 2005;54(8):1174-1179. doi:10.1136/gut.2004.050781

Examples

# Example 1: High Risk (Score >= 9)
# Age 55 (2), WBC 18 (2), BUN 30 (~10mmol) (2), INR 2.2 (3), Bili 15 (~256umol) (3)
# Score = 2+2+2+3+3 = 12
glasgow_alcoholic_hepatitis_score(55, 18, 30, 2.2, 15)

# Example 2: Low Risk (Score < 9)
# Age 40 (1), WBC 10 (1), BUN 10 (~3.5mmol) (1), INR 1.2 (1), Bili 2 (~34umol) (1)
# Score = 5
glasgow_alcoholic_hepatitis_score(40, 10, 10, 1.2, 2)