cliot (version 1.0.0)

imdc_risk_score: IMDC (Heng) Risk Model for Metastatic Renal Cell Carcinoma

Description

Calculates the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk score. This prognostic model stratifies patients with metastatic renal cell carcinoma (mRCC) treated with targeted therapy (VEGF-targeted agents) into Favorable, Intermediate, or Poor risk groups based on six clinical factors.

Usage

imdc_risk_score(time_to_therapy_lt_1yr, kps_lt_80, hemoglobin_lt_lln,
                calcium_gt_uln, neutrophils_gt_uln, platelets_gt_uln)

Value

A list containing:

IMDC_Score

The calculated total count of risk factors (Range 0-6).

Risk_Group

Classification (Favorable: 0, Intermediate: 1-2, Poor: >=3).

Median_Overall_Survival

Estimated median overall survival based on the original validation cohort.

Arguments

time_to_therapy_lt_1yr

Numeric (0 or 1). Less than 1 year from the time of diagnosis to the start of systemic therapy. (1 = Yes).

kps_lt_80

Numeric (0 or 1). Karnofsky Performance Status < 80%. (1 = Yes).

hemoglobin_lt_lln

Numeric (0 or 1). Hemoglobin less than the Lower Limit of Normal (LLN). (1 = Yes).

calcium_gt_uln

Numeric (0 or 1). Corrected Calcium greater than the Upper Limit of Normal (ULN). (1 = Yes).

neutrophils_gt_uln

Numeric (0 or 1). Neutrophil count greater than the Upper Limit of Normal (ULN). (1 = Yes).

platelets_gt_uln

Numeric (0 or 1). Platelet count greater than the Upper Limit of Normal (ULN). (1 = Yes).

References

Heng DY, Xie W, Regan MM, et al. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol. 2009;27(34):5794-5799. doi:10.1200/JCO.2008.21.4809

Examples

# Example 1: Poor Risk
# <1yr to tx, Low KPS, Anemia
# Score = 3
imdc_risk_score(1, 1, 1, 0, 0, 0)

# Example 2: Favorable Risk
# No risk factors present
# Score = 0
imdc_risk_score(0, 0, 0, 0, 0, 0)