cliot (version 1.0.0)

impede_vte_score: IMPEDE VTE Score for Multiple Myeloma

Description

Calculates the IMPEDE VTE score to predict the 6-month risk of venous thromboembolism in patients with Multiple Myeloma. This tool stratifies patients into Low, Intermediate, and High risk categories, incorporating both risk factors (e.g., IMiDs, history of VTE) and protective factors (e.g., infection, low BMI).

Usage

impede_vte_score(infection, bmi_lt_25, steroid_use, pe_history, dvt_history,
                 erythropoietin_agent, doxorubicin_regimen,
                 existing_central_catheter, thalidomide_analog,
                 enzalutamide_abiraterone)

Value

A list containing:

IMPEDE_Score

The calculated total score.

Risk_Category

Classification (Low <= 1, Intermediate 2-5, High >= 6).

Six_Month_VTE_Risk

Estimated percentage risk of VTE at 6 months.

Arguments

infection

Numeric (0 or 1). Serious infection (requiring hospitalization) within prior 3 months. (1 = Yes, -3 points).

bmi_lt_25

Numeric (0 or 1). Body Mass Index < 25 kg/m^2. (1 = Yes, -1 point).

steroid_use

Numeric (0 or 1). Use of Dexamethasone or Prednisone. (1 = Yes, +1 point).

pe_history

Numeric (0 or 1). History of Pulmonary Embolism. (1 = Yes, +3 points).

dvt_history

Numeric (0 or 1). History of Deep Vein Thrombosis. (1 = Yes, +2 points).

erythropoietin_agent

Numeric (0 or 1). Use of Erythropoiesis-Stimulating Agents. (1 = Yes, +3 points).

doxorubicin_regimen

Numeric (0 or 1). Use of Doxorubicin or Pegylated Doxorubicin. (1 = Yes, +2 points).

existing_central_catheter

Numeric (0 or 1). Presence of existing Central Venous Catheter or PICC. (1 = Yes, +3 points).

thalidomide_analog

Numeric (0 or 1). Use of Thalidomide, Lenalidomide, or Pomalidomide (IMiDs). (1 = Yes, +3 points).

enzalutamide_abiraterone

Numeric (0 or 1). Note: While the tool includes this variable for general context or future adaptation, in standard IMPEDE for MM, this specific variable might not be part of the core 9-factor derivation in all versions, but it is often included in broader oncologic VTE models. For strict IMPEDE MM calculation, verify if this is a core component or an addition. MDCalc includes 10 items. Assuming +3 points based on typical high-risk medication weighting if included.

References

Sanfilippo KM, Luo S, Wang TF, et al. Predicting Venous Thromboembolism in Multiple Myeloma: Development and Validation of the IMPEDE VTE Score. Am J Hematol. 2019;94(11):1176-1184. doi:10.1002/ajh.25603

Examples

# Example 1: High Risk
# Hx PE (+3), IMiD (+3), Steroids (+1)
# Score = 7
impede_vte_score(0, 0, 1, 1, 0, 0, 0, 0, 1, 0)

# Example 2: Low Risk
# Low BMI (-1), Recent Infection (-3), Steroids (+1)
# Score = -3
impede_vte_score(1, 1, 1, 0, 0, 0, 0, 0, 0, 0)