cliot (version 1.0.0)

international_iga_nephropathy_prediction: International IgA Nephropathy Prediction Tool

Description

Calculates the linear predictor for the risk of disease progression (50% decline in eGFR or ESRD) in patients with IgA Nephropathy at the time of biopsy. The model incorporates clinical data (eGFR, MAP, Proteinuria, Age, Race, Medications) and histologic findings (Oxford MEST score).

Usage

international_iga_nephropathy_prediction(age_at_biopsy, egfr_at_biopsy,
                                         proteinuria_g_day, map_mmhg, race,
                                         mest_m, mest_e, mest_s, mest_t,
                                         use_rasb, use_immunosuppression)

Value

A list containing:

Linear_Predictor

The calculated linear risk score. Higher values indicate higher risk.

Arguments

age_at_biopsy

Numeric. Age in years at the time of biopsy.

egfr_at_biopsy

Numeric. eGFR (mL/min/1.73m^2) at the time of biopsy.

proteinuria_g_day

Numeric. Urine protein excretion (g/day).

map_mmhg

Numeric. Mean Arterial Pressure (mmHg).

race

String. Patient race: "white", "chinese", "japanese", "other".

mest_m

Numeric (0 or 1). Mesangial hypercellularity (M0/M1).

mest_e

Numeric (0 or 1). Endocapillary hypercellularity (E0/E1).

mest_s

Numeric (0 or 1). Segmental glomerulosclerosis (S0/S1).

mest_t

Numeric (0, 1, or 2). Tubular atrophy/interstitial fibrosis (T0/T1/T2).

use_rasb

Numeric (0 or 1). Use of Renin-Angiotensin System Blockers at/before biopsy. (1 = Yes).

use_immunosuppression

Numeric (0 or 1). Use of Immunosuppression at/before biopsy. (1 = Yes).

References

Barbour SJ, Coppo R, Zhang H, et al. Evaluating a New International Risk-Prediction Tool in IgA Nephropathy. JAMA Intern Med. 2019;179(7):942-952. doi:10.1001/jamainternmed.2019.0600

Examples

# Example 1: High Risk
# 30yo, eGFR 45, Protein 2.5g, MAP 105, M1 E1 S1 T2, No meds, White
international_iga_nephropathy_prediction(30, 45, 2.5, 105, "white", 1, 1, 1, 2, 0, 0)

# Example 2: Low Risk
# 40yo, eGFR 90, Protein 0.5g, MAP 90, M0 E0 S0 T0, RASB Yes, Chinese
international_iga_nephropathy_prediction(40, 90, 0.5, 90, "chinese", 0, 0, 0, 0, 1, 0)