cliot (version 1.0.0)

iota_simple_rules_risk: IOTA Simple Rules Risk Assessment for Ovarian Tumors

Description

Calculates the estimated risk of malignancy for adnexal masses using the International Ovarian Tumor Analysis (IOTA) Simple Rules Risk (SRR) model. This model applies a logistic regression to the 10 standard IOTA Simple Rules features to provide a specific probability of malignancy, even when the standard rules classification is "Inconclusive".

Usage

iota_simple_rules_risk(b1_unilocular, b2_solid_lt_7mm, b3_acoustic_shadows,
                       b4_smooth_multi_lt_100mm, b5_no_blood_flow,
                       m1_irregular_solid, m2_ascites, m3_four_papillary_structures,
                       m4_irregular_multi_gt_100mm, m5_strong_blood_flow)

Value

A list containing:

Risk_of_Malignancy_Percent

The estimated percentage probability that the tumor is malignant.

Original_Classification

The outcome based on the original non-risk-calculating Simple Rules (Benign, Malignant, or Inconclusive).

Arguments

b1_unilocular

Numeric (0 or 1). B1: Unilocular cyst. (1 = Yes).

b2_solid_lt_7mm

Numeric (0 or 1). B2: Presence of solid components with largest diameter < 7 mm. (1 = Yes).

b3_acoustic_shadows

Numeric (0 or 1). B3: Presence of acoustic shadows. (1 = Yes).

b4_smooth_multi_lt_100mm

Numeric (0 or 1). B4: Smooth multilocular tumor with largest diameter < 100 mm. (1 = Yes).

b5_no_blood_flow

Numeric (0 or 1). B5: No blood flow (Color score 1). (1 = Yes).

m1_irregular_solid

Numeric (0 or 1). M1: Irregular solid tumor. (1 = Yes).

m2_ascites

Numeric (0 or 1). M2: Presence of ascites. (1 = Yes).

m3_four_papillary_structures

Numeric (0 or 1). M3: At least four papillary structures. (1 = Yes).

m4_irregular_multi_gt_100mm

Numeric (0 or 1). M4: Irregular multilocular solid tumor with largest diameter >= 100 mm. (1 = Yes).

m5_strong_blood_flow

Numeric (0 or 1). M5: Very strong blood flow (Color score 4). (1 = Yes).

References

Timmerman D, Van Calster B, Testa A, et al. Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group. Am J Obstet Gynecol. 2016;214(4):424-437. doi:10.1016/j.ajog.2016.01.007

Examples

# Example 1: Benign (Low Risk)
# Unilocular (B1), No flow (B5), No M features
iota_simple_rules_risk(1, 0, 0, 0, 1, 0, 0, 0, 0, 0)

# Example 2: Malignant (High Risk)
# Ascites (M2), Strong flow (M5), No B features
iota_simple_rules_risk(0, 0, 0, 0, 0, 0, 1, 0, 0, 1)

# Example 3: Inconclusive (Mixed features)
# Smooth Multi <100 (B4), but Strong flow (M5)
iota_simple_rules_risk(0, 0, 0, 1, 0, 0, 0, 0, 0, 1)