cliot (version 1.0.0)

ipss_r_mds_score: Revised International Prognostic Scoring System (IPSS-R) for MDS

Description

Calculates the IPSS-R score for risk stratification in patients with Myelodysplastic Syndromes (MDS). The score utilizes five variables: cytogenetics, bone marrow blast percentage, hemoglobin, platelet count, and absolute neutrophil count (ANC) to predict overall survival and risk of transformation to Acute Myeloid Leukemia (AML).

Usage

ipss_r_mds_score(hemoglobin_g_dl, anc_x10_9_l, platelet_count_x10_9_l,
                 bone_marrow_blasts_percent, cytogenetics_risk_group)

Value

A list containing:

IPSS_R_Score

The calculated total score (Range 0-10+).

Risk_Category

Classification (Very Low, Low, Intermediate, High, Very High).

Median_Overall_Survival

Estimated median survival time.

Time_to_25_Percent_AML_Evolution

Estimated time until 25% of patients progress to AML.

Arguments

hemoglobin_g_dl

Numeric. Hemoglobin level in g/dL. >=10: 0 pts. 8-<10: 1 pt. <8: 1.5 pts.

anc_x10_9_l

Numeric. Absolute Neutrophil Count in x10^9/L. >=0.8: 0 pts. <0.8: 0.5 pts.

platelet_count_x10_9_l

Numeric. Platelet count in x10^9/L. >=100: 0 pts. 50-<100: 0.5 pts. <50: 1 pt.

bone_marrow_blasts_percent

Numeric. Percentage of blasts in bone marrow. <=2: 0 pts. >2-<5: 1 pt. 5-10: 2 pts. >10: 3 pts.

cytogenetics_risk_group

String. Cytogenetic risk category based on karyotype. "very_good": -Y, del(11q). (0 pts). "good": Normal, del(5q), del(12p), del(20q), double including del(5q). (1 pt). "intermediate": del(7q), +8, +19, i(17q), any other single or double independent clones. (2 pts). "poor": -7, inv(3)/t(3q)/del(3q), double including -7/del(7q), Complex (3 abnormalities). (3 pts). "very_poor": Complex (>3 abnormalities). (4 pts).

References

Greenberg PL, Tuechler H, Schanz J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120(12):2454-2465. doi:10.1182/blood-2012-03-420489

Examples

# Example 1: High Risk
# Hb 9 (1), ANC 0.5 (0.5), Plt 40 (1), Blasts 8% (2), Poor Cyto (3)
# Score = 1 + 0.5 + 1 + 2 + 3 = 7.5
ipss_r_mds_score(9, 0.5, 40, 8, "poor")

# Example 2: Very Low Risk
# Hb 11 (0), ANC 1.5 (0), Plt 200 (0), Blasts 1% (0), Very Good Cyto (0)
# Score = 0
ipss_r_mds_score(11, 1.5, 200, 1, "very_good")