cliot (version 1.0.0)

iss_multiple_myeloma: International Staging System (ISS) for Multiple Myeloma

Description

Calculates the International Staging System (ISS) stage for multiple myeloma. This system stratifies patients into three prognostic groups based on serum beta-2 microglobulin and serum albumin levels.

Usage

iss_multiple_myeloma(beta2_microglobulin, albumin)

Value

A list containing:

ISS_Stage

The calculated stage (I, II, or III).

Median_Overall_Survival

Estimated median overall survival based on the original study data.

Arguments

beta2_microglobulin

Numeric. Serum Beta-2 Microglobulin level in mg/L.

albumin

Numeric. Serum Albumin level in g/dL.

References

Greipp PR, San Miguel J, Durie BG, et al. International staging system for multiple myeloma. J Clin Oncol. 2005;23(15):3412-3420. doi:10.1200/JCO.2005.04.242

Examples

# Example 1: Stage I (Low B2M, Normal Albumin)
# B2M 2.5, Alb 4.0
iss_multiple_myeloma(2.5, 4.0)

# Example 2: Stage III (High B2M)
# B2M 6.0, Alb 3.0
iss_multiple_myeloma(6.0, 3.0)

# Example 3: Stage II (Intermediate)
# B2M 4.0 (Between 3.5 and 5.5)
iss_multiple_myeloma(4.0, 3.5)