cliot (version 1.0.0)

isth_dic_score: ISTH Criteria for Disseminated Intravascular Coagulation (DIC)

Description

Calculates the score for Disseminated Intravascular Coagulation (DIC) based on the International Society on Thrombosis and Haemostasis (ISTH) criteria. This scoring system assesses platelet count, fibrin-related markers (e.g., D-dimer), prothrombin time prolongation, and fibrinogen levels to determine if a patient has overt DIC.

Usage

isth_dic_score(platelet_count, pt_prolongation_seconds, fibrinogen_g_l,
               fibrin_marker_increase)

Value

A list containing:

ISTH_DIC_Score

The calculated total score (Range 0-8).

Interpretation

Diagnostic interpretation based on the threshold of 5.

Arguments

platelet_count

Numeric. Platelet count in x 10^9/L (or x 10^3/uL). < 50: +2 points. 50-100: +1 point. > 100: 0 points.

pt_prolongation_seconds

Numeric. Prolongation of Prothrombin Time (PT) in seconds (Patient PT - Normal/Control PT). >= 6 sec: +2 points. 3 - < 6 sec: +1 point. < 3 sec: 0 points.

fibrinogen_g_l

Numeric. Fibrinogen level in g/L. < 1.0 g/L: +1 point. >= 1.0 g/L: 0 points.

fibrin_marker_increase

String. Level of increase in fibrin-related markers (e.g., D-dimer, FDP). "none": No increase (0 points). "moderate": Moderate increase (e.g., > Upper Limit of Normal; +2 points). "strong": Strong increase (e.g., > 5x Upper Limit of Normal; +3 points).

References

Taylor FB Jr, Toh CH, Hoots WK, et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86(5):1327-1330.

Examples

# Example 1: Overt DIC
# Platelets 40k (+2), Strong D-dimer (+3), PT prolonged 4s (+1), Fib 0.8 (+1)
# Score = 7
isth_dic_score(40, 4, 0.8, "strong")

# Example 2: Non-overt DIC
# Platelets 120k (0), Moderate D-dimer (+2), PT prolonged 1s (0), Fib 2.0 (0)
# Score = 2
isth_dic_score(120, 1, 2.0, "moderate")