cliot (version 1.0.0)

itas2010_score: Indian Takayasu Clinical Activity Score (ITAS2010)

Description

Calculates the ITAS2010 and ITAS-A scores to assess disease activity in patients with Takayasu Arteritis. The score assigns weighted points to new or worsening clinical features across systemic, cardiovascular, neurologic, renal, and other domains. A score of 1 or greater indicates active disease. The ITAS-A includes acute phase reactants (ESR/CRP) for enhanced sensitivity.

Usage

itas2010_score(systemic_symptoms, arthralgia, carotidynia, pulse_deficit, bruit,
               bp_discrepancy, claudication, hypertension, dyspnea, abdominal_pain,
               cutaneous_lesions, aortic_regurgitation, angina, heart_failure,
               syncope, tia, renal_failure, stroke, myocardial_infarction,
               bowel_ischemia, esr_crp_elevated = 0)

Value

A list containing:

ITAS2010_Score

The clinical activity score (Clinical features only).

ITAS_A_Score

The activity score including acute phase reactants.

Disease_Status

"Active" if score >= 1, otherwise "Inactive".

Arguments

systemic_symptoms

Numeric (0/1). Fever, malaise, or weight loss. (+1 pt).

arthralgia

Numeric (0/1). Arthralgia or myalgia. (+1 pt).

carotidynia

Numeric (0/1). Carotid tenderness. (+1 pt).

pulse_deficit

Numeric (0/1). Absent or unequal pulse. (+1 pt).

bruit

Numeric (0/1). Audible bruit. (+1 pt).

bp_discrepancy

Numeric (0/1). Blood pressure discrepancy between limbs. (+1 pt).

claudication

Numeric (0/1). Limb claudication. (+1 pt).

hypertension

Numeric (0/1). New or worsening hypertension. (+1 pt).

dyspnea

Numeric (0/1). Dyspnea or pleurisy. (+1 pt).

abdominal_pain

Numeric (0/1). Abdominal pain or nausea/vomiting. (+1 pt).

cutaneous_lesions

Numeric (0/1). Erythema nodosum or ulcers. (+1 pt).

aortic_regurgitation

Numeric (0/1). New or worsening AR. (+3 pts).

angina

Numeric (0/1). Angina pectoris. (+3 pts).

heart_failure

Numeric (0/1). Congestive heart failure. (+3 pts).

syncope

Numeric (0/1). Syncope or dizziness/vertigo. (+3 pts).

tia

Numeric (0/1). Transient Ischemic Attack or visual disturbance. (+3 pts).

renal_failure

Numeric (0/1). Renal failure. (+3 pts).

stroke

Numeric (0/1). Stroke. (+5 pts).

myocardial_infarction

Numeric (0/1). Myocardial infarction. (+5 pts).

bowel_ischemia

Numeric (0/1). Ischemic bowel. (+5 pts).

esr_crp_elevated

Numeric (0/1). Elevated ESR or CRP (for ITAS-A). (+1 pt).

References

Misra DP, Rathore U, Patro P, et al. Disease Activity Indices in Takayasu Arteritis: A Systematic Review and Meta-Analysis. Rheumatol Ther. 2021. Jayakumar P, et al. Development and validation of the Indian Takayasu Clinical Activity Score (ITAS2010). Indian J Rheumatol. 2010.

Examples

# Example 1: Active Disease
# Pulse deficit (+1), Claudication (+1), Elevated ESR (+1)
# ITAS2010 = 2, ITAS-A = 3
itas2010_score(0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1)

# Example 2: Severe Activity
# Stroke (+5), Hypertension (+1)
# ITAS2010 = 6
itas2010_score(0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0)