cliot (version 1.0.0)

iwg2_alzheimers_criteria: IWG-2 Criteria for Alzheimer's Disease Diagnosis

Description

Applies the International Working Group 2 (IWG-2) criteria (2014) for the diagnosis of Alzheimer's Disease. These criteria define AD as a clinico-biological entity, requiring both a specific clinical phenotype (typical amnestic or atypical) and in vivo evidence of Alzheimer's pathology (pathophysiological biomarkers).

Usage

iwg2_alzheimers_criteria(clinical_phenotype_present,
                         pathophysiological_marker_positive,
                         autosomal_dominant_mutation_present)

Value

A list containing:

IWG2_Diagnosis

The diagnostic category determined by the criteria.

Classification

General classification (Definite, Supported, At Risk, or Not Met).

Arguments

clinical_phenotype_present

Numeric (0 or 1). Presence of a specific clinical phenotype of AD (Typical Amnestic or Atypical: Posterior Cortical Atrophy, Logopenic Aphasia, Frontal Variant). (1 = Yes).

pathophysiological_marker_positive

Numeric (0 or 1). Presence of a positive pathophysiological biomarker (Low CSF Abeta42 + High Tau, or Positive Amyloid PET). (1 = Yes).

autosomal_dominant_mutation_present

Numeric (0 or 1). Presence of a proven autosomal dominant mutation (PSEN1, PSEN2, APP). (1 = Yes).

References

Dubois B, Feldman HH, Jacova C, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 2014;13(6):614-629. doi:10.1016/S1474-4422(14)70090-0

Examples

# Example 1: Diagnosis Confirmed
# Phenotype present (1), Positive Biomarker (1), No mutation (0)
iwg2_alzheimers_criteria(1, 1, 0)

# Example 2: Preclinical (Asymptomatic at risk)
# No symptoms (0), Positive Biomarker (1), No mutation (0)
iwg2_alzheimers_criteria(0, 1, 0)