cliot (version 1.0.0)

kinetic_egfr: Kinetic Estimated Glomerular Filtration Rate (KeGFR)

Description

Calculates the Kinetic eGFR, a metric that adjusts the standard eGFR for rapid changes in serum creatinine levels. This provides a more accurate estimation of renal function in the context of Acute Kidney Injury (AKI), where creatinine production and excretion are not in steady state. The Baseline eGFR is calculated internally using the CKD-EPI 2021 (Race-Free) equation.

Usage

kinetic_egfr(initial_creatinine, final_creatinine, time_hours,
             baseline_creatinine, age, sex, weight_kg)

Value

A list containing:

Kinetic_eGFR

The calculated kinetic GFR in mL/min/1.73m^2.

Baseline_eGFR

The steady-state eGFR derived from the baseline creatinine.

Arguments

initial_creatinine

Numeric. The first serum creatinine measurement in the interval (mg/dL).

final_creatinine

Numeric. The second serum creatinine measurement in the interval (mg/dL).

time_hours

Numeric. The time elapsed between the initial and final creatinine measurements in hours.

baseline_creatinine

Numeric. The patient's stable baseline serum creatinine (mg/dL). This is used to estimate the steady-state creatinine production rate.

age

Numeric. Patient age in years.

sex

String. Patient sex ("Male" or "Female").

weight_kg

Numeric. Patient weight in kilograms. Used to estimate the volume of distribution (Total Body Water).

References

Chen S. Retooling the Creatinine Clearance Equation to Estimate Kinetic GFR when the Plasma Creatinine Is Changing acutely. J Am Soc Nephrol. 2013;24(6):877-888. doi:10.1681/ASN.2012070653

Examples

# Example 1: Developing AKI
# Cr rose from 1.0 to 1.5 over 24 hours. Baseline was 1.0.
# Age 60, Male, 80kg
kinetic_egfr(1.0, 1.5, 24, 1.0, 60, "male", 80)

# Example 2: Recovery from AKI
# Cr fell from 3.0 to 2.0 over 24 hours. Baseline was 1.0.
# Age 60, Male, 80kg
kinetic_egfr(3.0, 2.0, 24, 1.0, 60, "male", 80)