cliot (version 1.0.0)

lille_model_score: Lille Model for Alcoholic Hepatitis

Description

Calculates the Lille Model score to predict 6-month mortality in patients with severe alcoholic hepatitis treated with steroids. It is used at Day 7 of treatment to determine whether the patient is a "responder" or "non-responder," helping guide the decision to continue or stop corticosteroids.

Usage

lille_model_score(age, renal_insufficiency, albumin, bilirubin_day0,
                  bilirubin_day7, pt_seconds, bilirubin_units = "mg/dL",
                  albumin_units = "g/dL")

Value

A list containing:

Lille_Model_Score

The calculated probability score (0-1).

Interpretation

Clinical guidance (Responder < 0.45, Non-responder >= 0.45).

Arguments

age

Numeric. Patient age in years.

renal_insufficiency

Numeric (0 or 1). Creatinine > 1.3 mg/dL (> 115 µmol/L) or CrCl < 40 mL/min. (1 = Yes).

albumin

Numeric. Serum albumin level.

bilirubin_day0

Numeric. Total bilirubin on Day 0 (start of treatment).

bilirubin_day7

Numeric. Total bilirubin on Day 7 of treatment.

pt_seconds

Numeric. Prothrombin Time in seconds.

bilirubin_units

String. Units for bilirubin. "mg/dL" (default) or "umol/L".

albumin_units

String. Units for albumin. "g/dL" (default) or "g/L".

References

Louvet A, Naveau S, Abdelnour M, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology. 2007;45(6):1348-1354. doi:10.1002/hep.21607

Examples

# Example 1: Responder
# Age 45, No Renal, Alb 3.5 g/dL, Bili 10->5 mg/dL, PT 15s
lille_model_score(45, 0, 3.5, 10, 5, 15)

# Example 2: Non-Responder
# Age 55, Renal Yes, Alb 2.5 g/dL, Bili 15->14 mg/dL, PT 25s
lille_model_score(55, 1, 2.5, 15, 14, 25)