cliot (version 1.0.0)

manchester_sclc_score: Manchester Score for Prognosis in Small Cell Lung Cancer (SCLC)

Description

Calculates the Manchester Score to predict prognosis in patients with Small Cell Lung Cancer (SCLC). The score stratifies patients into Good, Intermediate, or Poor risk groups based on LDH, Sodium, Alkaline Phosphatase, Karnofsky Performance Status, Bicarbonate, and Disease Stage.

Usage

manchester_sclc_score(ldh_level, ldh_uln, sodium, alk_phos_level, alk_phos_uln,
                      kps, bicarbonate, stage_extensive)

Value

A list containing:

Manchester_Score

The calculated total score (Range 0-6).

Prognosis_Group

Classification (Good 0-1, Intermediate 2-3, Poor 4-6).

Median_Survival

Estimated median survival time.

Two_Year_Survival

Estimated 2-year survival percentage.

Arguments

ldh_level

Numeric. Patient's serum Lactate Dehydrogenase level (U/L).

ldh_uln

Numeric. Laboratory Upper Limit of Normal for LDH. (Score adds 1 if LDH >= ULN).

sodium

Numeric. Serum Sodium level (mmol/L or mEq/L). (Score adds 1 if Na < 132).

alk_phos_level

Numeric. Serum Alkaline Phosphatase level (U/L).

alk_phos_uln

Numeric. Laboratory Upper Limit of Normal for Alkaline Phosphatase. (Score adds 1 if ALP >= 1.5x ULN).

kps

Numeric. Karnofsky Performance Status score (0-100). (Score adds 1 if KPS < 60).

bicarbonate

Numeric. Serum Bicarbonate (HCO3) level (mmol/L or mEq/L). (Score adds 1 if HCO3 < 24).

stage_extensive

Numeric (0 or 1). Is the disease stage Extensive? (1 = Yes, +1 point; 0 = Limited, 0 points).

References

Cerny T, Blair V, Anderson H, et al. Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients. Int J Cancer. 1987;39(2):146-149. doi:10.1002/ijc.2910390204

Examples

# Example 1: Good Prognosis
# Normal labs, High KPS, Limited Stage
manchester_sclc_score(150, 250, 140, 80, 120, 90, 26, 0)

# Example 2: Poor Prognosis
# High LDH, Low Na, High ALP, Low KPS, Low HCO3, Extensive Stage
# Score = 6
manchester_sclc_score(300, 250, 130, 200, 100, 50, 20, 1)