cliot (version 1.0.0)

mekhail_motzer_score: Mekhail Extension of the Motzer Score for Metastatic RCC

Description

Calculates the Mekhail Extension of the Motzer Score (MSKCC Score) for prognosis in patients with metastatic Renal Cell Carcinoma (mRCC) who have received prior immunotherapy or chemotherapy. This model adds "Metastasis in >= 2 organs" to the original 5 Motzer risk factors.

Usage

mekhail_motzer_score(time_to_treatment_lt_1y, kps_lt_80, hemoglobin_low,
                     calcium_high, ldh_high, metastasis_sites_ge_2)

Value

A list containing:

Mekhail_Score

The total count of risk factors present (Range 0-6).

Risk_Group

Classification (Favorable: 0, Intermediate: 1-2, Poor: >=3).

Median_Overall_Survival

Estimated median survival time based on the validation cohort.

Arguments

time_to_treatment_lt_1y

Numeric (0 or 1). Time from initial diagnosis to start of systemic treatment < 1 year. (1 = Yes).

kps_lt_80

Numeric (0 or 1). Karnofsky Performance Status < 80%. (1 = Yes).

hemoglobin_low

Numeric (0 or 1). Serum hemoglobin less than the lower limit of normal. (1 = Yes).

calcium_high

Numeric (0 or 1). Corrected serum calcium > 10 mg/dL (2.5 mmol/L). (1 = Yes).

ldh_high

Numeric (0 or 1). Lactate Dehydrogenase > 1.5x Upper Limit of Normal. (1 = Yes).

metastasis_sites_ge_2

Numeric (0 or 1). Metastasis in 2 or more organs. (1 = Yes).

References

Mekhail TM, Abou-Jawde RM, Boumerhi G, et al. Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously treated metastatic renal cell carcinoma. J Clin Oncol. 2005;23(4):832-841. doi:10.1200/JCO.2005.05.179

Examples

# Example 1: Poor Risk
# KPS 70 (1), Anemia (1), 3 Metastatic Sites (1)
# Score = 3
mekhail_motzer_score(0, 1, 1, 0, 0, 1)

# Example 2: Favorable Risk
# No risk factors
# Score = 0
mekhail_motzer_score(0, 0, 0, 0, 0, 0)