mipi_lymphoma_score: Mantle Cell Lymphoma International Prognostic Index (MIPI)

Description

Calculates the MIPI score to predict overall survival in patients with advanced-stage mantle cell lymphoma (MCL). The score is a continuous variable derived from age, ECOG performance status, lactate dehydrogenase (LDH) ratio, and white blood cell (WBC) count.

Usage

mipi_lymphoma_score(age, ecog_score, ldh_level, ldh_uln, wbc_count)

Value

A list containing:

MIPI_Score: The calculated prognostic score.
Risk_Group: Classification (Low < 5.7, Intermediate 5.7-6.2, High >= 6.2).
Median_Overall_Survival: Estimated median survival time based on the original cohort.

Arguments

age: Numeric. Patient age in years.
ecog_score: Numeric. Eastern Cooperative Oncology Group (ECOG) performance status (0-4). Scores 0-1 are weighted as 0; scores 2-4 are weighted as 1 in the algorithm.
ldh_level: Numeric. Patient's serum LDH level.
ldh_uln: Numeric. The laboratory's Upper Limit of Normal for LDH.
wbc_count: Numeric. White Blood Cell count in x10^9/L (or cells/uL / 1000).

References

Hoster E, Dreyling M, Klapper W, et al. A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood. 2008;111(2):558-565. doi:10.1182/blood-2007-06-095331

Examples

Run this code


# Example 1: High Risk
# Age 80 (2.8), ECOG 3 (0.7), LDH 1000/200 (Ratio 5 -> log10(5)=0.7, 1.367*0.7=0.95),
#WBC 50 (log10(50)=1.7, 0.94*1.7=1.6)
# Sum = 2.8 + 0.7 + 0.95 + 1.6 = 6.05 (Intermediate).
mipi_lymphoma_score(80, 3, 1000, 200, 50)

# Example 2: Low Risk
# Age 50, ECOG 0, LDH 150 (ULN 200 -> 0.75), WBC 5
# Score = 1.76 + 0 + (1.367 * -0.12) + (0.9393 * 0.7) = 1.76 - 0.16 + 0.66 = 2.26
mipi_lymphoma_score(50, 0, 150, 200, 5)

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