cliot (version 1.0.0)

nincds_adrda_criteria: NINCDS-ADRDA Criteria for Alzheimer's Disease

Description

Evaluates the NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association) clinical criteria for the diagnosis of Alzheimer's Disease. The criteria classify patients into Definite, Probable, or Possible Alzheimer's Disease based on clinical findings and exclusion of other causes.

Usage

nincds_adrda_criteria(dementia_established, multiple_cognitive_deficits,
                      progressive_worsening, no_consciousness_disturbance,
                      onset_age_40_90, absence_of_other_disorders,
                      histopathology_evidence = 0)

Value

A list containing:

Diagnosis

The resulting diagnostic classification: "Definite Alzheimer's Disease", "Probable Alzheimer's Disease", "Possible Alzheimer's Disease", or "Unlikely Alzheimer's Disease".

Arguments

dementia_established

Numeric (0 or 1). Dementia established by clinical examination and documented by the Mini-Mental Test, Blessed Dementia Scale, or similar examination. (1 = Yes).

multiple_cognitive_deficits

Numeric (0 or 1). Deficits in two or more areas of cognition. (1 = Yes).

progressive_worsening

Numeric (0 or 1). Progressive worsening of memory and other cognitive functions. (1 = Yes).

no_consciousness_disturbance

Numeric (0 or 1). No disturbance of consciousness. (1 = Yes).

onset_age_40_90

Numeric (0 or 1). Onset between ages 40 and 90. (1 = Yes).

absence_of_other_disorders

Numeric (0 or 1). Absence of systemic disorders or other brain diseases that could account for the progressive deficits in memory and cognition. (1 = Yes).

histopathology_evidence

Numeric (0 or 1). Histopathologic evidence of Alzheimer's Disease obtained from biopsy or autopsy. (1 = Yes). Required for "Definite" diagnosis.

References

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939-944. doi:10.1212/wnl.34.7.939

Examples

# Example 1: Probable AD
# All core criteria met, no biopsy
nincds_adrda_criteria(1, 1, 1, 1, 1, 1, 0)

# Example 2: Definite AD
# All core criteria met + Biopsy confirmed
nincds_adrda_criteria(1, 1, 1, 1, 1, 1, 1)

# Example 3: Possible AD (Comorbidity)
# All core criteria met EXCEPT absence of other disorders (0)
nincds_adrda_criteria(1, 1, 1, 1, 1, 0, 0)