cliot (version 1.0.0)

oxygenation_index: Oxygenation Index (OI)

Description

Calculates the Oxygenation Index (OI), a dimensionless number used primarily in neonatal and pediatric intensive care to assess the severity of hypoxic respiratory failure. It integrates Mean Airway Pressure (MAP) to quantify the intensity of ventilatory support required to maintain oxygenation. High values correlate with increased mortality and are used as criteria for advanced interventions like HFOV or ECMO.

Usage

oxygenation_index(mean_airway_pressure, fio2_percent, pao2)

Value

A list containing:

Oxygenation_Index

The calculated OI value.

Interpretation

Clinical guidance based on standard severity thresholds.

Arguments

mean_airway_pressure

Numeric. Mean Airway Pressure (MAP) in cm H2O.

fio2_percent

Numeric. Fraction of Inspired Oxygen as a percentage (e.g., 100 for 100% oxygen).

pao2

Numeric. Partial pressure of arterial oxygen in mmHg.

Details

The formula is: $$OI = \frac{FiO_2 (\%) \times MAP}{PaO_2}$$ Common clinical thresholds:

• OI > 25: High risk, consider HFOV/iNO.

• OI > 40: Very high risk, consider ECMO.

References

Ortiz RM, Cilley RE, Bartlett RH. Extracorporeal membrane oxygenation in pediatric respiratory failure. Pediatr Clin North Am. 1987;34(1):39-46. Trachsel D, McCrindle BW, Nakagawa S, Bohn D. Oxygenation index predicts mortality in children with acute hypoxemic respiratory failure. Am J Respir Crit Care Med. 2005;172(2):206-211. doi:10.1164/rccm.200405-625OC

Examples

# Example 1: Severe Failure (ECMO candidate)
# MAP 30, FiO2 100%, PaO2 60
# OI = (100 * 30) / 60 = 50
oxygenation_index(30, 100, 60)

# Example 2: Mild/Moderate
# MAP 15, FiO2 50%, PaO2 80
# OI = (50 * 15) / 80 = 9.38
oxygenation_index(15, 50, 80)