cliot (version 1.0.0)

pbsc_collection_volume: Peripheral Blood Stem Cell (PBSC) Collection Volume Calculator

Description

Calculates the total blood volume (in Liters) that must be processed through an apheresis machine to achieve a specific target yield of CD34+ stem cells. The calculation is based on the patient's weight, the pre-apheresis peripheral CD34+ cell count, and the estimated collection efficiency of the machine.

Usage

pbsc_collection_volume(weight_kg, pre_cd34_count, target_yield,
                       collection_efficiency_percent = 50)

Value

A list containing:

Volume_to_Process_Liters

The estimated blood volume to process to reach the target yield.

Arguments

weight_kg

Numeric. Patient weight in kilograms.

pre_cd34_count

Numeric. Peripheral blood CD34+ cell count (cells/uL or cells/mm^3).

target_yield

Numeric. The desired CD34+ cell yield in millions of cells per kg (x 10^6/kg). Common targets range from 2 to 5 x 10^6/kg.

collection_efficiency_percent

Numeric. The estimated efficiency of the apheresis machine in collecting CD34+ cells (0-100). Defaults to 50%. Standard range is typically 30-50%.

Details

The formula used is: $$Volume (L) = \frac{Target Yield \times Weight}{CD34_{pre} \times Efficiency}$$ Where:

• Target Yield is in \(10^6\) cells/kg

• \(CD34_{pre}\) is in cells/\(\mu\)L

• Efficiency is a decimal (Percent/100)

Note: The units cancel out such that the result is directly in Liters.

References

Hester JP, et al. Stem Cell Collection. In: Apheresis: Principles and Practice. 3rd ed.

Examples

# Example 1: Standard Collection
# 70kg patient, CD34 count 20/uL, Target 5 million/kg, 50% efficiency
# Vol = (5 * 70) / (20 * 0.5) = 350 / 10 = 35 Liters
pbsc_collection_volume(70, 20, 5, 50)

# Example 2: High Efficiency, Low Count
# 80kg, CD34 10/uL, Target 2 million/kg, 40% efficiency
# Vol = (2 * 80) / (10 * 0.4) = 160 / 4 = 40 Liters
pbsc_collection_volume(80, 10, 2, 40)