cliot (version 1.0.0)

rai_cll_staging: Rai Staging System for Chronic Lymphocytic Leukemia (CLL)

Description

Calculates the Rai Stage for patients with Chronic Lymphocytic Leukemia (CLL). This staging system stratifies patients into Low, Intermediate, and High risk groups based on the presence of lymphocytosis, lymphadenopathy, organomegaly (hepatomegaly or splenomegaly), anemia, and thrombocytopenia.

Usage

rai_cll_staging(lymphocytosis, lymphadenopathy, organomegaly,
                hemoglobin_lt_11, platelets_lt_100)

Value

A list containing:

Rai_Stage

The calculated stage (0, I, II, III, or IV).

Risk_Category

Risk stratification (Low, Intermediate, High).

Median_Survival

Historical median survival estimates based on the original 1975 cohort data.

Arguments

lymphocytosis

Numeric (0 or 1). Presence of absolute lymphocytosis (>5,000/uL in blood and >=30% in marrow). (1 = Yes).

lymphadenopathy

Numeric (0 or 1). Presence of lymphadenopathy. (1 = Yes).

organomegaly

Numeric (0 or 1). Presence of hepatomegaly or splenomegaly. (1 = Yes).

hemoglobin_lt_11

Numeric (0 or 1). Hemoglobin < 11 g/dL (Anemia). (1 = Yes).

platelets_lt_100

Numeric (0 or 1). Platelets < 100,000/uL (Thrombocytopenia). (1 = Yes).

References

Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46(2):219-234.

Examples

# Example 1: High Risk (Stage IV)
# Lymphocytosis, Anemia, Thrombocytopenia
rai_cll_staging(1, 1, 1, 1, 1)

# Example 2: Low Risk (Stage 0)
# Lymphocytosis only
rai_cll_staging(1, 0, 0, 0, 0)