cliot (version 1.0.0)

sledai_2k_score: Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K)

Description

Calculates the SLEDAI-2K score to assess global disease activity in patients with Systemic Lupus Erythematosus (SLE). It assesses the presence of 24 specific clinical and laboratory variables over the last 10 days (or since the last visit).

Usage

sledai_2k_score(seizure, psychosis, organic_brain_syndrome, visual_disturbance,
                cranial_nerve_disorder, lupus_headache, cva, vasculitis,
                arthritis, myositis, urinary_casts, hematuria, proteinuria,
                pyuria, rash, alopecia, mucosal_ulcers, pleurisy, pericarditis,
                low_complement, increased_dna_binding, fever, thrombocytopenia,
                leukopenia)

Value

A list containing:

SLEDAI_2K_Score

The calculated total score.

Disease_Activity

Interpretation of the score (No Activity, Mild, Moderate, High, Very High).

Arguments

seizure

Numeric (0 or 1). Recent onset of seizure. (1 = Yes, 8 points).

psychosis

Numeric (0 or 1). Altered ability to function in normal activity due to severe disturbance in the perception of reality. (1 = Yes, 8 points).

organic_brain_syndrome

Numeric (0 or 1). Altered mental function with impaired orientation, memory, or other intellectual function. (1 = Yes, 8 points).

visual_disturbance

Numeric (0 or 1). Retinal changes of SLE. (1 = Yes, 8 points).

cranial_nerve_disorder

Numeric (0 or 1). New onset of sensory or motor neuropathy involving cranial nerves. (1 = Yes, 8 points).

lupus_headache

Numeric (0 or 1). Severe, persistent headache. (1 = Yes, 8 points).

cva

Numeric (0 or 1). New onset of cerebrovascular accident (CVA). (1 = Yes, 8 points).

vasculitis

Numeric (0 or 1). Ulceration, gangrene, tender finger nodules, periungual infarction, splinter hemorrhages, or biopsy/angiogram proof. (1 = Yes, 8 points).

arthritis

Numeric (0 or 1). More than 2 joints with pain and signs of inflammation (i.e., tenderness, swelling, or effusion). (1 = Yes, 4 points).

myositis

Numeric (0 or 1). Proximal muscle aching/weakness, associated with elevated CPK/aldolase or EMG changes or biopsy. (1 = Yes, 4 points).

urinary_casts

Numeric (0 or 1). Heme-granular or red blood cell casts. (1 = Yes, 4 points).

hematuria

Numeric (0 or 1). >5 red blood cells/high power field. (1 = Yes, 4 points).

proteinuria

Numeric (0 or 1). >0.5g/24 hours. (1 = Yes, 4 points).

pyuria

Numeric (0 or 1). >5 white blood cells/high power field. (1 = Yes, 4 points).

rash

Numeric (0 or 1). Inflammatory type rash. (1 = Yes, 2 points).

alopecia

Numeric (0 or 1). Abnormal, patchy or diffuse loss of hair. (1 = Yes, 2 points).

mucosal_ulcers

Numeric (0 or 1). Oral or nasal ulceration. (1 = Yes, 2 points).

pleurisy

Numeric (0 or 1). Pleuritic chest pain with pleural rub or effusion or pleural thickening. (1 = Yes, 2 points).

pericarditis

Numeric (0 or 1). Pericardial pain with rub or effusion or EKG confirmation. (1 = Yes, 2 points).

low_complement

Numeric (0 or 1). Decrease in CH50, C3, or C4 below the lower limit of normal. (1 = Yes, 2 points).

increased_dna_binding

Numeric (0 or 1). Increased DNA binding by Farr assay (above normal). (1 = Yes, 2 points).

fever

Numeric (0 or 1). >38 degrees C. (1 = Yes, 1 point).

thrombocytopenia

Numeric (0 or 1). <100,000 platelets/mm^3. (1 = Yes, 1 point).

leukopenia

Numeric (0 or 1). <3,000 white blood cells/mm^3. (1 = Yes, 1 point).

References

Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002;29(2):288-291.

Examples

# Example 1: Moderate Activity
# Arthritis (4), Rash (2), Fever (1)
# Score = 7
sledai_2k_score(0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0)

# Example 2: High Activity
# Vasculitis (8), Low Complement (2), Increased DNA Binding (2)
# Score = 12
sledai_2k_score(0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0)