cliot (version 1.0.0)

slicc_sle_criteria: SLICC Criteria for Systemic Lupus Erythematosus (SLE)

Description

Evaluates the 2012 SLICC (Systemic Lupus International Collaborating Clinics) criteria for the diagnosis of Systemic Lupus Erythematosus. Diagnosis requires either: 1) Biopsy-proven lupus nephritis with positive ANA or Anti-dsDNA, OR 2) At least 4 criteria met, including at least one clinical criterion and one immunologic criterion.

Usage

slicc_sle_criteria(acute_cutaneous_lupus, chronic_cutaneous_lupus, oral_ulcers,
                   alopecia, synovitis, serositis, renal_clinical, neurologic,
                   hemolytic_anemia, leukopenia_lymphopenia, thrombocytopenia,
                   ana, anti_dsdna, anti_sm, antiphospholipid_antibody,
                   low_complement, direct_coombs, biopsy_proven_nephritis)

Value

A list containing:

Diagnosis

"Systemic Lupus Erythematosus (SLE)" or "Criteria Not Met".

Total_Criteria_Met

Count of total criteria met (adjusted for Coombs rule).

Breakdown

Breakdown of Clinical and Immunologic counts.

Arguments

acute_cutaneous_lupus

Numeric (0/1). Presence of acute cutaneous lupus (e.g., malar rash).

chronic_cutaneous_lupus

Numeric (0/1). Presence of chronic cutaneous lupus (e.g., discoid rash).

oral_ulcers

Numeric (0/1). Oral or nasal ulcers.

alopecia

Numeric (0/1). Non-scarring alopecia.

synovitis

Numeric (0/1). Synovitis involving 2 or more joints.

serositis

Numeric (0/1). Serositis (pleuritis or pericarditis).

renal_clinical

Numeric (0/1). Renal criteria (urine protein/creatinine ratio or red blood cell casts).

neurologic

Numeric (0/1). Neurologic criteria (seizures, psychosis, etc.).

hemolytic_anemia

Numeric (0/1). Hemolytic anemia.

leukopenia_lymphopenia

Numeric (0/1). Leukopenia (<4000/mm3) or Lymphopenia (<1000/mm3).

thrombocytopenia

Numeric (0/1). Thrombocytopenia (<100,000/mm3).

ana

Numeric (0/1). Positive ANA (Antinuclear Antibody).

anti_dsdna

Numeric (0/1). Positive Anti-dsDNA.

anti_sm

Numeric (0/1). Positive Anti-Sm.

antiphospholipid_antibody

Numeric (0/1). Positive Antiphospholipid antibody.

low_complement

Numeric (0/1). Low complement (C3, C4, or CH50).

direct_coombs

Numeric (0/1). Positive Direct Coombs test. (Note: Counts as immunologic criterion only in the absence of hemolytic anemia).

biopsy_proven_nephritis

Numeric (0/1). Biopsy-proven lupus nephritis.

References

Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64(8):2677-2686. doi:10.1002/art.34473

Examples

# Example 1: Diagnosis via Criteria Count
# Malar rash (1), Arthritis (1), Renal (1), ANA (1) -> 3 Clinical, 1 Immuno, Total 4
slicc_sle_criteria(1, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0)

# Example 2: Diagnosis via Biopsy
# No clinical symptoms, but Biopsy Nephritis (1) and ANA (1)
slicc_sle_criteria(0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1)