cliot (version 1.0.0)

sokal_cml_index: Sokal Index for Chronic Myelogenous Leukemia (CML)

Description

Calculates the Sokal Index to prognosticate risk in patients with Chronic Myelogenous Leukemia (CML). The score is based on age, spleen size, platelet count, and percentage of blasts in the peripheral blood. It stratifies patients into Low, Intermediate, or High risk groups regarding survival.

Usage

sokal_cml_index(age, spleen_size_cm, platelet_count, blasts_percent)

Value

A list containing:

Sokal_Score

The calculated relative risk score.

Risk_Group

Risk classification (Low < 0.8, Intermediate 0.8-1.2, High > 1.2).

Arguments

age

Numeric. Patient age in years.

spleen_size_cm

Numeric. Spleen size in centimeters below the costal margin (0 if not palpable).

platelet_count

Numeric. Platelet count in x10^9/L (e.g., 300 for 300,000/uL).

blasts_percent

Numeric. Percentage of blasts in peripheral blood.

References

Sokal JE, Cox EB, Baccarani M, et al. Prognostic discrimination in "good-risk" chronic granulocytic leukemia. Blood. 1984;63(4):789-799.

Examples

# Example 1: Low Risk
# 35yo, Spleen 0cm, Plt 300, Blasts 1%
# Score approx 0.6
sokal_cml_index(35, 0, 300, 1)

# Example 2: High Risk
# 60yo, Spleen 10cm, Plt 700, Blasts 5%
# Score > 1.2
sokal_cml_index(60, 10, 700, 5)