cliot (version 1.0.0)

ssign_rcc_score: SSIGN Score for Renal Cell Carcinoma (RCC)

Description

Calculates the SSIGN (Stage, Size, Grade, and Necrosis) Score to predict cancer-specific survival outcomes in patients with clear cell Renal Cell Carcinoma (ccRCC) after radical or partial nephrectomy.

Usage

ssign_rcc_score(pathologic_t_stage, lymph_node_status, metastasis_status,
                tumor_size_ge_5cm, fuhrman_grade, tumor_necrosis_present)

Value

A list containing:

SSIGN_Score

The calculated total score (Range 0-18).

Est_5_Year_Survival

Estimated 5-year cancer-specific survival percentage.

Arguments

pathologic_t_stage

String. Pathologic T Stage (2002 TNM). "t1a": 0 pts. "t1b": 2 pts. "t2": 3 pts. "t3a", "t3b", "t3c": 4 pts. "t4": 5 pts.

lymph_node_status

String. Regional Lymph Node status. "n0" or "nx": 0 pts. "n1" or "n2": 2 pts.

metastasis_status

Numeric (0 or 1). Distant metastasis (M1). (1 = Yes, +4 pts).

tumor_size_ge_5cm

Numeric (0 or 1). Tumor size >= 5 cm. (1 = Yes, +2 pts).

fuhrman_grade

Numeric (1-4). Fuhrman Nuclear Grade. 1 or 2: 0 pts. 3: 1 pt. 4: 3 pts.

tumor_necrosis_present

Numeric (0 or 1). Presence of tumor necrosis. (1 = Yes, +2 pts).

References

Frank I, Blute ML, Cheville JC, et al. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol. 2002;168(6):2395-2400. doi:10.1016/S0022-5347(05)64153-5

Examples

# Example 1: High Risk
# T3a (+4), N0 (0), M0 (0), Size 6cm (+2), Grade 4 (+3), Necrosis (+2)
# Score = 11
ssign_rcc_score("t3a", "n0", 0, 1, 4, 1)

# Example 2: Low Risk
# T1a (0), N0 (0), M0 (0), Size 3cm (0), Grade 2 (0), No Necrosis (0)
# Score = 0
ssign_rcc_score("t1a", "n0", 0, 0, 2, 0)