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cliot (version 1.0.0)

tenecteplase_dosing: Tenecteplase (TNKase) Dosing Calculator

Description

Calculates the recommended dose of Tenecteplase for the treatment of Acute Myocardial Infarction (STEMI) or Acute Ischemic Stroke. Dosing for STEMI is based on weight tiers, while dosing for stroke is calculated as 0.25 mg/kg with a maximum limit.

Usage

tenecteplase_dosing(weight_kg, indication = "stemi")

Value

A list containing:

Recommended_Dose_mg

The calculated dose in milligrams.

Volume_to_Administer_mL

The volume to administer in milliliters (based on standard 5 mg/mL reconstitution).

Arguments

weight_kg

Numeric. Patient weight in kilograms.

indication

String. Clinical indication for treatment. Options: "stemi" (default) or "stroke". STEMI Dosing: <60 kg: 30 mg 60-69 kg: 35 mg 70-79 kg: 40 mg 80-89 kg: 45 mg >=90 kg: 50 mg Stroke Dosing: 0.25 mg/kg (Max 25 mg).

References

TNKase (Tenecteplase) [Package Insert]. South San Francisco, CA: Genentech, Inc. Haley EC Jr, et al. Tenecteplase in acute ischemic stroke: results of a randomized controlled trial. Stroke. 2010;41(4):707-711.

Examples

Run this code

# Example 1: STEMI, 75 kg
# Tier 70-79kg -> 40 mg
tenecteplase_dosing(75, "stemi")

# Example 2: Stroke, 110 kg
# 0.25 * 110 = 27.5 mg -> Capped at 25 mg
tenecteplase_dosing(110, "stroke")

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