cliot (version 1.0.0)

therapeutic_plasmapheresis: Therapeutic Plasmapheresis (Plasma Exchange) Calculator

Description

Calculates the estimated Total Blood Volume (TBV), Estimated Plasma Volume (EPV), and the total volume of plasma to be removed/exchanged based on patient weight, hematocrit, and the desired number of plasma volumes to exchange.

Usage

therapeutic_plasmapheresis(weight_kg, hematocrit_percent, exchange_volume_pv = 1.0)

Value

A list containing:

Total_Blood_Volume_mL

Estimated Total Blood Volume.

Estimated_Plasma_Volume_mL

Estimated total plasma volume of the patient.

Volume_to_Exchange_mL

The volume of plasma to be removed/exchanged to meet the target.

Arguments

weight_kg

Numeric. Patient weight in kilograms.

hematocrit_percent

Numeric. Patient's hematocrit as a percentage (0-100).

exchange_volume_pv

Numeric. The target number of plasma volumes to exchange (e.g., 1.0, 1.2, 1.5). Defaults to 1.0.

Details

The calculations use the following standard estimations (Gilcher's rule of thumb): $$TBV (mL) = Weight (kg) \times 70 mL/kg$$ $$EPV (mL) = TBV \times (1 - Hct)$$ $$Exchange Volume (mL) = EPV \times Target PV$$ Note: 70 mL/kg is a standard estimate for adults; actual blood volume may vary based on body composition and demographics.

References

Kaplan AA. Therapeutic plasma exchange: A technical overview. J Clin Apher. 2013;28(1):3-10.

Examples

# Example 1: Standard 1.0 PV exchange
# 70kg patient, Hct 40%
# TBV = 4900, EPV = 4900 * 0.6 = 2940 mL
therapeutic_plasmapheresis(70, 40, 1.0)

# Example 2: 1.5 PV exchange for TTP
# 80kg patient, Hct 30%
# TBV = 5600, EPV = 5600 * 0.7 = 3920 mL
# Exchange = 3920 * 1.5 = 5880 mL
therapeutic_plasmapheresis(80, 30, 1.5)