cliot (version 1.0.0)

us_medped_fh_criteria: US MEDPED Diagnostic Criteria for Familial Hypercholesterolemia (FH)

Description

Calculates the US MEDPED (Make Early Diagnosis to Prevent Early Deaths) diagnostic criteria for Familial Hypercholesterolemia. The diagnosis is based on age-specific total cholesterol thresholds and the degree of relationship to a known relative with FH.

Usage

us_medped_fh_criteria(age, total_cholesterol, relative_with_fh, units = "mg/dL")

Value

A list containing:

Diagnosis

"Diagnosed with Familial Hypercholesterolemia (FH)" or "Does Not Meet Criteria for FH".

Threshold_Used_mg_dL

The specific cholesterol cutoff used for the assessment.

Arguments

age

Numeric. Patient age in years.

total_cholesterol

Numeric. Total cholesterol level.

relative_with_fh

String. The degree of relationship to a relative diagnosed with FH. Options: "first_degree" (Parent, Sibling, Child). "second_degree" (Grandparent, Aunt/Uncle, Niece/Nephew, Half-sibling). "third_degree" (First Cousin). "general_population" (No known relative with FH).

units

String. Units for cholesterol input. Options: "mg/dL" (default) or "mmol/L".

Details

Thresholds (mg/dL) for diagnosis: First Degree: <20y (220), 20-29y (240), 30-39y (270), >=40y (290). Second Degree: <20y (230), 20-29y (250), 30-39y (280), >=40y (300). Third Degree: <20y (240), 20-29y (260), 30-39y (290), >=40y (310). General Population: <20y (270), 20-29y (290), 30-39y (340), >=40y (360).

References

Williams RR, Hunt SC, Schumacher MC, et al. Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics. Am J Cardiol. 1993;72(2):171-176. doi:10.1016/0002-9149(93)90155-6

Examples

# Example 1: FH Diagnosed
# 35yo, Cholesterol 300 mg/dL, First-degree relative with FH
us_medped_fh_criteria(35, 300, "first_degree")

# Example 2: Not FH
# 50yo, Cholesterol 250 mg/dL, General Population
us_medped_fh_criteria(50, 250, "general_population")