cobenrich (version 1.0.1)

avetrteff2: Compute the average subpopulation treatment effect and the standardized average subpopulation treatment effect when two biomarkers are involved

Description

Compute the average subpopulation treatment effect and the standardized average subpopulation treatment effect when two biomarkers are involved

Usage

avetrteff2(z1z2, kappa, rhovec, sigma, muminusmu0)

Value

a list of three numbers: delta is the average subpopulation treatment effect, lambda is the standardized average subpopulation treatment effect, and cVar is the variance with respect to the truncated distribution with specified cutoff values

Arguments

z1z2

a numeric vector of two numbers that are standardized biomarker values

kappa

a number of the correlation coefficient between two biomarkers

rhovec

a numeric vector of two correlation coefficients between the output and two biomarkers

sigma

a number of the standard deviation of outcome

muminusmu0

a number of the difference between the mean of outcome and the minimal clinically important treatment effect

Author

Jiangtao Gou

References

Zhang, F. and Gou, J. (2025). Using multiple biomarkers for patient enrichment in two-stage clinical designs. Technical Report.

Examples

x1x2 <- c(2, 1)
nu1nu2 <- c(0,0)
tau1tau2 <- c(1,1)
z1z2 <- (x1x2 - nu1nu2)/tau1tau2
muminusmu0 <- 1.8
kappa <- 0.1
sigma <- 1
rhovec <- c(0.1, 0.2)
avetrteff2(z1z2, kappa, rhovec, sigma, muminusmu0)