Psoriasis

Psoriasis,DEexprs,sampleLabel,cogena_result


An example dataset of Psoriasis. This dataset is used for 
illustration of the usage of <code>cogena</code> package. It has been normalised
the expression profling using <code>rma</code> method, filtered some 
non-informative genes using <code>MetaDE</code> package and analysed the 
differentially expressed genes using <code>limma</code> package with 
the cut-off adjuested p-value 0.05 and abs(logFC) >=1.


datasets

cogena is a workflow for co-expressed gene-set enrichment analysis.
It aims to discovery smaller scale, but highly correlated cellular events that
may be of great biological relevance. A novel pipeline for drug discovery and
drug repositioning based on the cogena workflow is proposed. Particularly,
candidate drugs can be predicted based on the gene expression of disease-related
data, or other similar drugs can be identified based on the gene expression
of drug-related data. Moreover, the drug mode of action can be disclosed by
the associated pathway analysis. In summary, cogena is a flexible workflow for
various gene set enrichment analysis for co-expressed genes, with a focus on
pathway/GO analysis and drug repositioning.

Zhilong Jia

cogena

co-expressed gene-set enrichment analysis

Psoriasis function

two objects: DEexprs and sampleLabel.
<dl>
<dt>DEexprs</dt><dd>expression of DEG. There are 706 DEGs and 116 samples.</dd> <dt>sampleLabel</dt><dd>the label of sample, There are 58 control and 58 Psoriasis.</dd> </dl>

Format

<a href="http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13355">http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13355</a>

Source

<a href = 'http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13355'>http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13355</a>

Psoriasis: Psoriasis dataset.

Description

Arguments

Format

Source