coin (version 0.4-2)

alpha: Genetic Components of Alcoholism

Description

Levels of expressed alpha synuclein mRNA in three groups of allele lengths of NACP-REP1.

Usage

data("alpha")

source

D. B"onsch, T. Lederer, U. Reulbach, T. Hothorn, J. Kornhuber and S. Bleich (2005), Joint Analysis of the NACP-REP1 Marker Within the Alpha Synuclein Gene Concludes Association with Alcohol Dependence. Human Molecular Genetics, 14, 7, 967--971.

Details

Various studies have linked alcohol dependence phenotypes to chromosome 4. One candidate gene is NACP (non-amyloid component of plaques), coding for alpha synuclein. B"onsch et al. (2005) found longer alleles of NACP-REP1 in alcohol-dependent patients compared with healthy controls and report that the allele lengths show some association with levels of expressed alpha synuclein mRNA.

Examples

data("alpha", package = "coin")
  boxplot(elevel ~ alength, data = alpha)
  kruskal_test(elevel ~ alength, data = alpha)