coin (version 0.4-2)

sphase: S-phase Fraction of Tumor Cells

Description

S-phase fraction of tumor cells in breast cancer patients.

Usage

data("sphase")

source

J. Pfisterer, F. Kommoss, W. Sauerbrei, D. Menzel, M. Kiechle, E. Giese, M. Hilgarth and A. Pfleiderer (1995), DNA flow cytometry in node positive breast cancer: Prognostic value and correlation to morphological and clinical factors. Analytical and Quantitative Cytology and Histology 7(6), 406--412.

Details

The data have been used to address the question whether a simple cutpoint in S-phase fraction can be used to discriminate between patients with good and bad prognosis (for example in Hothorn & Lausen, 2003).

References

Torsten Hothorn & Berthold Lausen (2003), On the Exact Distribution of Maximally Selected Rank Statistics. Computational Statistics & Data Analysis 43, 121--137.

Examples

data("sphase", package = "coin")
maxstat_test(Surv(RFS, event) ~ SPF, data = sphase)

### reproduce the test statistic reported in Hothorn & Lausen (2003)
maxstat_test(Surv(RFS, event) ~ SPF, data = sphase, 
    ytrafo = function(data) trafo(data, surv_trafo = function(x) 
        logrank_trafo(x, ties.method = "HL")))