coin (version 1.0-7)

sphase: S-phase Fraction of Tumor Cells

Description

S-phase fraction of tumor cells in breast cancer patients.

Usage

data("sphase")

source

J. Pfisterer, F. Kommoss, W. Sauerbrei, D. Menzel, M. Kiechle, E. Giese, M. Hilgarth & A. Pfleiderer (1995). DNA flow cytometry in node positive breast cancer: Prognostic value and correlation to morphological and clinical factors. Analytical and Quantitative Cytology and Histology 7(6), 406--412.

Details

The data have been used to address the question whether a simple cutpoint in S-phase fraction can be used to discriminate between patients with good and bad prognosis (for example in Hothorn & Lausen, 2003).

References

Torsten Hothorn & Berthold Lausen (2003). On the exact distribution of maximally selected rank statistics. Computational Statistics & Data Analysis 43, 121--137.

Examples

maxstat_test(Surv(RFS, event) ~ SPF, data = sphase)

  ### reproduce the test statistic reported in Hothorn & Lausen (2003)
  maxstat_test(Surv(RFS, event) ~ SPF, data = sphase, 
      ytrafo = function(data) trafo(data, surv_trafo = function(x) 
          logrank_trafo(x, ties.method = "HL")))