coin (version 1.1-0)

alpha: Genetic Components of Alcoholism

Description

Levels of expressed alpha synuclein mRNA in three groups of allele lengths of NACP-REP1.

Usage

alpha

encoding

UTF-8

source

Bönsch{Boensch}, D., Lederer, T., Reulbach, U., Hothorn, T., Kornhuber, J. and Bleich, S. (2005). Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. Human Molecular Genetics 14(7), 967--971.

Details

Various studies have linked alcohol dependence phenotypes to chromosome 4. One candidate gene is NACP (non-amyloid component of plaques), coding for alpha synuclein. Bönsch{Boensch} et al. (2005) found longer alleles of NACP-REP1 in alcohol-dependent patients compared with healthy controls and reported that the allele lengths show some association with levels of expressed alpha synuclein mRNA.

References

Hothorn, T., Hornik, K., van de Wiel, M. A. and Zeileis, A. (2006). A Lego system for conditional inference. The American Statistician 60(3), 257--263.

Examples

## Boxplots
boxplot(elevel ~ alength, data = alpha)

## Asymptotic Kruskal-Wallis test
kruskal_test(elevel ~ alength, data = alpha)