average_piks

Average of priors: pnk, pak and pck

A Bayesian method for Phenome-wide association studies (PheWAS) that identifies causal associations between genetic variants and traits, while simultaneously addressing confounding due to linkage disequilibrium. For details see
Manipur et al (2024, Nature Communications) <doi:10.1038/s41467-024-49990-8>.

Ichcha Manipur

cophescan

Adaptation of the Coloc Method for PheWAS

Chris Wallace

average_piks function

<dl><dt>params</dt>
<dd>Vector of parameters: \(\alpha\), \(\beta\) and \(\gamma\)</dd>
<dt>nsnps</dt>
<dd>number of snps</dd>
<dt>covar_vec</dt>
<dd>Vector of the covariate</dd>
<dt>nits</dt>
<dd>Number of iterations run in mcmc</dd>
<dt>thin</dt>
<dd>thinning</dd>
<dt>covar</dt>
<dd>logical: was the covariate inflormation used? default: False</dd></dl>

Arguments

Average of priors: pnk, pak and pck — average_piks

<dl>

<dt>params</dt>
<dd>Vector of parameters: \(\alpha\), \(\beta\) and \(\gamma\)</dd>


<dt>nsnps</dt>
<dd>number of snps</dd>


<dt>covar_vec</dt>
<dd>Vector of the covariate</dd>


<dt>nits</dt>
<dd>Number of iterations run in mcmc</dd>


<dt>thin</dt>
<dd>thinning</dd>


<dt>covar</dt>
<dd>logical: was the covariate inflormation used? default: False</dd>

</dl>

average_piks: Average of priors: pnk, pak and pck

Description

Usage

Value

Arguments