cpk (version 1.3-1)

css.fn: css function

Description

Calculates css (steady-state) drug concentration in ng/mL, which is the same as ug/mL.

Usage

css.fn(f, dpo, di, cl, ar, wtkg)

Arguments

f

is bioavailability.

dpo

is oral dose administered in ug.

di

is the dosing interval in h.

cl

is the total clearance rate in L/kg/h.

ar

is stepwise accumulation ratio.

wtkg

is patient weight in kg.

Value

Returns css in mg/L and ug/L

References

See cpk-package help.

Examples

f <- 0.74; dpo <- 3440; di <- 4; cl <- 0.37; ar <-1.4; wtkg <- 86;
css <-css.fn(f, dpo, di, cl, ar, wtkg)