crmPack (version 0.2.7)

This is a class of design based on DLE responses using the '>LogisticIndepBeta model model and efficacy responses using '>ModelEff model class without DLE and efficacy samples. It contain all slots in '>RuleDesign and '>TDDesign class object

This is a class of design based on DLE responses using the '>LogisticIndepBeta model model and efficacy responses using '>ModelEff model class with DLE and efficacy samples.It contain all slots in '>RuleDesign and '>TDsamplesDesign class object

This is a class which captures the trial simulations from designs using pseudo model. The design for DLE only responses and model from '>ModelTox class object. It contains all slots from '>GeneralSimulations object. Additional slots fit and stopReasons compared to the general class '>GeneralSimulations.

This is a class which captures the trial simulations design using both the DLE and efficacy responses. The design of model from '>ModelTox class and the efficacy model from '>EffFlexi class It contains all slots from '>GeneralSimulations, '>PseudoSimulations and '>PseudoDualSimulations object. In comparison to the parent class '>PseudoDualSimulations, it contains additional slots to capture the sigma2betaW estimates.

This is a class which captures the trial simulations design using both the DLE and efficacy responses. The design of model from '>ModelTox class and the efficacy model from '>ModelEff class (except '>EffFlexi class). It contains all slots from '>GeneralSimulations and '>PseudoSimulations object. In comparison to the parent class '>PseudoSimulations, it contains additional slots to capture the dose-efficacy curve and the sigma2 estimates.

This plot method can be applied to '>PseudoDualFlexiSimulations objects in order to summarize them graphically. Possible types of plots at the moment are:

trajectory

Summary of the trajectory of the simulated trials

dosesTried

Average proportions of the doses tested in patients

sigma2

The variance of the efficacy responses

sigma2betaW

The variance of the random walk model

You can specify one or both of these in the type argument.

Plot the fitted dose-effcacy curve using a model from '>ModelEff class with samples

Plot the fitted dose-DLE curve using a '>ModelTox class model with samples

This is a methods to simulate dose escalation procedure using both DLE and efficacy responses. This is a method based on the '>DualResponsesDesign where DLEmodel used are of '>ModelTox class object and efficacy model used are of '>ModelEff class object. In addition, no DLE and efficacy samples are involved or generated in the simulation process

This is a methods to simulate dose escalation procedure using both DLE and efficacy responses. This is a method based on the '>DualResponsesSamplesDesign where DLEmodel used are of '>ModelTox class object and efficacy model used are of '>ModelEff class object (special case is '>EffFlexi class model object). In addition, DLE and efficacy samples are involved or generated in the simulation process

This is a class of design based only on DLE responses using the 'LogisticIndepBeta' class model and DLE samples are also used. In addition to the slots in the more simple '>RuleDesign, objects of this class contain:

This is a methods to simulate dose escalation procedure only using the DLE responses. This is a method based on the '>TDsamplesDesign where model used are of '>ModelTox class object DLE samples are also used

Update method for the 'EffFlexi' Model class. This is a method to update estimates both for the flexible form model and the random walk model (see details in '>EffFlexi class object) when new data or new observations of responses are available and added in.

This is a methods to simulate dose escalation procedure only using the DLE responses. This is a method based on the '>TDDesign where model used are of '>ModelTox class object and no samples are involved.