EffFlexi

the corresponding dose levels for the pseudo efficacy responses

Effdose

the prior variance of the efficacy responses which can be specified 
with a single positive scalar or with two positive scalar values fot the shape <code>a</code> and 
the rate <code>b</code> parameters of the inverse gamma distribtuion.

sigma2

the prior variance of the random walk model used for smoothing which can be
specified with a single postive scalar or with two positive scalars representing the shape <code>a</code>
and the rate <code>b</code> parameter of the inverse gamma distribution.

sigma2betaW

used for smoothing data for this efficacy model. That is either the "RW1", the 
first-order random walk model or "RW2", the second-order random walk model is used of the mean
efficacy responses.

smooth

the input data to update estimates of model parameters and 
follow the <code><a href="/link/?package=crmPack&version=1.0.0" datadual'="" data-mini-rdoc="crmPack::"></a>'>DataDual</code> object class specification

data

Initialization function for the "EffFlexi" class

methods

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Giuseppe Palermo

crmPack

Object-Oriented Implementation of CRM Designs

Daniel Sabanes Bove

Wai Yin Yeung

Thomas Jaki

EffFlexi function

the input data to update estimates of model parameters and 
follow the <code><a href='<a href='DataDual'></a>'>DataDual</a></code> object class specification

EffFlexi: Initialization function for the "EffFlexi" class

Description

Usage

Arguments

Value