GeneralSimulationsSummary-class

.GeneralSimulationsSummary

Note that objects should not be created by users, therefore no
initialization function is provided for this class.

classes

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

GeneralSimulationsSummary-class function

<dl>
<dt><code>target</code></dt>
<dd>target toxicity interval</dd></dl>
<dt><code>targetDoseInterval</code></dt>
<dd>corresponding target dose interval</dd>
<dt><code>nsim</code></dt>
<dd>number of simulations</dd>
<dt><code>propDLTs</code></dt>
<dd>proportions of DLTs in the trials</dd>
<dt><code>meanToxRisk</code></dt>
<dd>mean toxicity risks for the patients</dd>
<dt><code>doseSelected</code></dt>
<dd>doses selected as MTD</dd>
<dt><code>toxAtDosesSelected</code></dt>
<dd>true toxicity at doses selected</dd>
<dt><code>propAtTarget</code></dt>
<dd>Proportion of trials selecting target MTD</dd>
<dt><code>doseMostSelected</code></dt>
<dd>dose most often selected as MTD</dd>
<dt><code>obsToxRateAtDoseMostSelected</code></dt>
<dd>observed toxicity rate at dose most often
selected</dd>
<dt><code>nObs</code></dt>
<dd>number of patients overall</dd>
<dt><code>nAboveTarget</code></dt>
<dd>number of patients treated above target tox interval</dd>
<dt><code>doseGrid</code></dt>
<dd>the dose grid that has been used</dd>
<dt><code>placebo</code></dt>
<dd>set to TRUE (default is FALSE) for a design with placebo</dd>

Slots

Class for the summary of general simulations output — GeneralSimulationsSummary-class

<dl>
<dt><code>target</code></dt>
<dd>target toxicity interval</dd>


<dt><code>targetDoseInterval</code></dt>
<dd>corresponding target dose interval</dd>


<dt><code>nsim</code></dt>
<dd>number of simulations</dd>


<dt><code>propDLTs</code></dt>
<dd>proportions of DLTs in the trials</dd>


<dt><code>meanToxRisk</code></dt>
<dd>mean toxicity risks for the patients</dd>


<dt><code>doseSelected</code></dt>
<dd>doses selected as MTD</dd>


<dt><code>toxAtDosesSelected</code></dt>
<dd>true toxicity at doses selected</dd>


<dt><code>propAtTarget</code></dt>
<dd>Proportion of trials selecting target MTD</dd>


<dt><code>doseMostSelected</code></dt>
<dd>dose most often selected as MTD</dd>


<dt><code>obsToxRateAtDoseMostSelected</code></dt>
<dd>observed toxicity rate at dose most often
selected</dd>


<dt><code>nObs</code></dt>
<dd>number of patients overall</dd>


<dt><code>nAboveTarget</code></dt>
<dd>number of patients treated above target tox interval</dd>


<dt><code>doseGrid</code></dt>
<dd>the dose grid that has been used</dd>


<dt><code>placebo</code></dt>
<dd>set to TRUE (default is FALSE) for a design with placebo</dd>


</dl>

GeneralSimulationsSummary-class: Class for the summary of general simulations output

Description

Arguments

Slots