IncrementsRelativeParts-class

.IncrementsRelativeParts

Note that this only works in conjunction with <code>DataParts</code>
objects. If the part 2 will just be started in the next cohort, then the
next maximum dose will be either <code>dltStart</code> (e.g. -1) shift of the last
part 1 dose in case of a DLT in part 1, or <code>cleanStart</code> shift (e.g. 0)
in case of no DLTs in part 1. If part 1 will still be on in the next cohort,
then the next dose level will be the next higher dose level in the
<code>part1Ladder</code> of the data object. If part 2 has been started before,
the usual relative increment rules apply, see
<code>IncrementsRelative</code>.

classes

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

IncrementsRelativeParts-class function

<dl>
<dt><code>dltStart</code></dt>
<dd>integer giving the dose level increment for starting part 2
in case of a DLT in part 1</dd></dl>
<dt><code>cleanStart</code></dt>
<dd>integer giving the dose level increment for starting part 2
in case of a DLT in part 1. If this is less or equal to 0, then the part 1
ladder will be used to find the maximum next dose. If this is larger than 0,
then the relative increment rules will be applied to find the next maximum
dose level.</dd>

Slots

Increments control based on relative differences in intervals,
with special rules for part 1 and beginning of part 2 — IncrementsRelativeParts-class

<dl>
<dt><code>dltStart</code></dt>
<dd>integer giving the dose level increment for starting part 2
in case of a DLT in part 1</dd>


<dt><code>cleanStart</code></dt>
<dd>integer giving the dose level increment for starting part 2
in case of a DLT in part 1. If this is less or equal to 0, then the part 1
ladder will be used to find the maximum next dose. If this is larger than 0,
then the relative increment rules will be applied to find the next maximum
dose level.</dd>


</dl>

IncrementsRelativeParts-class: Increments control based on relative differences in intervals, with special rules for part 1 and beginning of part 2

Description

Arguments

Slots

Examples