PseudoDualSimulationsSummary-class

.PseudoDualSimulationsSummary

It contains all slots from <code>PseudoSimulationsSummary</code> object. In addition to 
the slots in the parent class <code>PseudoSimulationsSummary</code>, it contains four 
more slots for the efficacy model fit information.

class

Implements a wide range of model-based dose
escalation designs, ranging from classical and modern continual
reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
dual-endpoint designs taking into account a biomarker/efficacy outcome. The
focus is on Bayesian inference, making it very easy to setup a new design
with its own JAGS code. However, it is also possible to implement 3+3
designs for comparison or models with non-Bayesian estimation. The whole
package is written in a modular form in the S4 class system, making it very
flexible for adaptation to new models, escalation or stopping rules.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of CRM Designs

Wai Yin Yeung

Giuseppe Palermo

Thomas Jaki

PseudoDualSimulationsSummary-class function

<dl>
<dt><code>targetGstar</code></dt>
<dd>the target dose level such that its gain value is at maximum</dd></dl>
<dt><code>targetGstarAtDoseGrid</code></dt>
<dd>the dose level at dose Grid closest and below Gstar</dd>
<dt><code>GstarSummary</code></dt>
<dd>the six-number table summary (lowest, 25th, 50th (median), 75th percentile, mean 
and highest value) of the final Gstar values obtained across all simulations</dd>
<dt><code>ratioGstarSummary</code></dt>
<dd>the six-number summary table of the ratios of the upper to the lower 95%
credibility intervals of the final Gstar across all simulations</dd>
<dt><code>EffFitAtDoseMostSelected</code></dt>
<dd>fitted expected mean efficacy value at dose most often
selected</dd>
<dt><code>meanEffFit</code></dt>
<dd>list with mean, lower (2.5
efficacy value at each dose level.</dd>

Slots

Class for the summary of the dual responses simulations using pseudo models — PseudoDualSimulationsSummary-class

<dl>
<dt><code>targetGstar</code></dt>
<dd>the target dose level such that its gain value is at maximum</dd>


<dt><code>targetGstarAtDoseGrid</code></dt>
<dd>the dose level at dose Grid closest and below Gstar</dd>


<dt><code>GstarSummary</code></dt>
<dd>the six-number table summary (lowest, 25th, 50th (median), 75th percentile, mean 
and highest value) of the final Gstar values obtained across all simulations</dd>


<dt><code>ratioGstarSummary</code></dt>
<dd>the six-number summary table of the ratios of the upper to the lower 95%
credibility intervals of the final Gstar across all simulations</dd>


<dt><code>EffFitAtDoseMostSelected</code></dt>
<dd>fitted expected mean efficacy value at dose most often
selected</dd>


<dt><code>meanEffFit</code></dt>
<dd>list with mean, lower (2.5
efficacy value at each dose level.</dd>


</dl>

PseudoDualSimulationsSummary-class: Class for the summary of the dual responses simulations using pseudo models

Description

Arguments

Slots

Details