DASimulations-class

.DASimulations

DASimulations

.DefaultDASimulations

<a href="https://lifecycle.r-lib.org/articles/stages.html#stable"><img src="figures/lifecycle-stable.svg?package=crmPack&version=2.0.0" alt="[Stable]"></a>
This class captures the trial simulations from DA based designs.
In comparison to the parent class <code>Simulations</code>,
it contains additional slots to capture the time to DLT fits, additional
parameters and the trial duration.

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanes Bove et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

DASimulations-class function

<dl><dt>trial_duration</dt>
<dd>(<code>numeric</code>) see <code>DASimulations</code></dd>
<dt>...</dt>
<dd>additional parameters from <code>Simulations</code></dd></dl>

Arguments

<dl>
<dt><code>trial_duration</code></dt>
<dd>(<code>numeric</code>) the vector of trial duration values for all simulations.</dd></dl>

Slots

<a href='https://lifecycle.r-lib.org/articles/stages.html#stable'><img src='figures/lifecycle-stable.svg' alt='[Stable]' /></a>
This class captures the trial simulations from DA based designs.
In comparison to the parent class <code>Simulations</code>,
it contains additional slots to capture the time to DLT fits, additional
parameters and the trial duration.

DASimulations — DASimulations-class

<dl>

<dt>trial_duration</dt>
<dd>(<code>numeric</code>) see <code>DASimulations</code></dd>


<dt>...</dt>
<dd>additional parameters from <code>Simulations</code></dd>

</dl>

<dl>
<dt><code>trial_duration</code></dt>
<dd>(<code>numeric</code>) the vector of trial duration values for all simulations.</dd>


</dl>

<code>DASimulations</code>

DASimulations-class: `DASimulations`

Description

Usage

Arguments

Slots