DLTLikelihood

This is a helper function for the <code>fitPEM</code> methods below.

internal

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanes Bove et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

DLTLikelihood function

<dl><dt>lambda</dt>
<dd>the vector of piecewise hazards</dd>
<dt>Tmax</dt>
<dd>the end of the time interval for DLTs</dd></dl>

Arguments

Likelihood of DLTs in each interval — DLTLikelihood

<dl>

<dt>lambda</dt>
<dd>the vector of piecewise hazards</dd>


<dt>Tmax</dt>
<dd>the end of the time interval for DLTs</dd>

</dl>

Likelihood of DLTs in each interval

DLTLikelihood: Likelihood of DLTs in each interval

Description

Usage

Value

Arguments