IncrementsDoseLevels-class

.IncrementsDoseLevels

IncrementsDoseLevels

.DefaultIncrementsDoseLevels

<a href="https://lifecycle.r-lib.org/articles/stages.html#stable"><img src="figures/lifecycle-stable.svg?package=crmPack&version=2.0.0" alt="[Stable]"></a>
<code>IncrementsDoseLevels</code> is the class for increments control based on the
number of dose levels.

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanes Bove et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

IncrementsDoseLevels-class function

<dl><dt>levels</dt>
<dd>(<code>count</code>) see slot definition.</dd>
<dt>basis_level</dt>
<dd>(<code>string</code>) see slot definition.</dd></dl>

Arguments

<dl>
<dt><code>levels</code></dt>
<dd>(<code>count</code>) maximum number of dose levels to increment for
the next dose. It defaults to 1, which means that no dose skipping is
allowed, i.e. the next dose can be maximum one level higher than the current
base dose. The current base dose level is the dose level used to increment
from (see <code>basis_level</code> parameter).</dd></dl>
<dt><code>basis_level</code></dt>
<dd>(<code>string</code>) defines the current base dose level. It can
take one out of two possible values: <code>last</code> or <code>max</code>.
If <code>last</code> is specified (default), the current base dose level is set to the
last dose given. If <code>max</code> is specified, then the current base dose level is
set to the maximum dose level given.</dd>

Slots

<a href='https://lifecycle.r-lib.org/articles/stages.html#stable'><img src='figures/lifecycle-stable.svg' alt='[Stable]' /></a>
<code>IncrementsDoseLevels</code> is the class for increments control based on the
number of dose levels.

IncrementsDoseLevels — IncrementsDoseLevels-class

<dl>

<dt>levels</dt>
<dd>(<code>count</code>) see slot definition.</dd>


<dt>basis_level</dt>
<dd>(<code>string</code>) see slot definition.</dd>

</dl>

<dl>
<dt><code>levels</code></dt>
<dd>(<code>count</code>) maximum number of dose levels to increment for
the next dose. It defaults to 1, which means that no dose skipping is
allowed, i.e. the next dose can be maximum one level higher than the current
base dose. The current base dose level is the dose level used to increment
from (see <code>basis_level</code> parameter).</dd>


<dt><code>basis_level</code></dt>
<dd>(<code>string</code>) defines the current base dose level. It can
take one out of two possible values: <code>last</code> or <code>max</code>.
If <code>last</code> is specified (default), the current base dose level is set to the
last dose given. If <code>max</code> is specified, then the current base dose level is
set to the maximum dose level given.</dd>


</dl>

<code>IncrementsDoseLevels</code>

IncrementsDoseLevels-class: `IncrementsDoseLevels`

Description

Usage

Arguments

Slots

Examples